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Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma.
DC Field | Value | Language |
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dc.contributor.author | 김규언 | - |
dc.contributor.author | 손명현 | - |
dc.date.accessioned | 2015-05-19T16:57:59Z | - |
dc.date.available | 2015-05-19T16:57:59Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107274 | - |
dc.description.abstract | BACKGROUND: TNF-alpha and IL-13, two pivotal pro-inflammatory cytokines, are increased in asthmatic airways and may be linked to asthma susceptibility and/or bronchial hyperresponsiveness (BHR). OBJECTIVE: We investigated the association between the TNF-alpha-308G/A polymorphism and asthma susceptibility or asthma-related phenotypes in Korean children with asthma, and tested for a combined effect with IL-13 polymorphisms. METHODS: Asthmatic children (n=719) and non-atopic healthy control children (n=243) were evaluated for asthma phenotypes including total serum IgE and BHR to methacholine. Genotypes were determined by PCR-restriction fragment length polymorphism analysis. RESULTS: The allele frequency of TNF-alpha-308A in asthmatics (14.1%) was higher than that in control children [8.7%, odds ratio (OR) 1.72, 95% confidence interval (CI) 1.05-2.82]. Significantly lower PC(20) values were found in asthmatic children carrying one or two copies of the TNF-alpha risk allele (-308A) vs. those homozygous for the common allele (P=0.026). Combined analysis revealed that atopic asthmatic children co-inherited the risk alleles of TNF-alpha-308G/A and IL-13 +2044G/A more frequently than control children (aOR 1.91, 95% CI 1.00-3.65), and asthmatic children co-inheriting both risk alleles had significantly lower PC(20) values vs. asthmatic children homozygous for the common alleles (P=0.024). CONCLUSION: The TNF-alpha promoter polymorphism (-308G/A) may be associated with asthma susceptibility and BHR in Korean children with asthma. In addition, there appears to be a synergistic effect between the TNF-alpha promoter polymorphism and an IL-13 coding region polymorphism in terms of asthma susceptibility and BHR in this population. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Bronchial Hyperreactivity/genetics* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-13/genetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics* | - |
dc.title | Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | H-B. Kim | - |
dc.contributor.googleauthor | M-J. Kang | - |
dc.contributor.googleauthor | S-Y. Lee | - |
dc.contributor.googleauthor | H-S. Jin | - |
dc.contributor.googleauthor | J-H. Kim | - |
dc.contributor.googleauthor | B-S. Kim | - |
dc.contributor.googleauthor | S-O. Jang | - |
dc.contributor.googleauthor | Y-C. Lee | - |
dc.contributor.googleauthor | M-H. Sohn | - |
dc.contributor.googleauthor | K-E. Kim | - |
dc.contributor.googleauthor | S-J. Hong | - |
dc.identifier.doi | 10.1111/j.1365-2222.2008.02965.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.relation.journalcode | J00548 | - |
dc.identifier.eissn | 1365-2222 | - |
dc.identifier.pmid | 18341619 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2008.02965.x | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | bronchial hyperresponsiveness | - |
dc.subject.keyword | combined effect | - |
dc.subject.keyword | IL‐13 | - |
dc.subject.keyword | TNF‐α | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.rights.accessRights | not available | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 774 | - |
dc.citation.endPage | 780 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL ALLERGY, Vol.38(5) : 774-780, 2008 | - |
dc.identifier.rimsid | 48250 | - |
dc.type.rims | ART | - |
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