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Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma.

DC Field Value Language
dc.contributor.author김규언-
dc.contributor.author손명현-
dc.date.accessioned2015-05-19T16:57:59Z-
dc.date.available2015-05-19T16:57:59Z-
dc.date.issued2008-
dc.identifier.issn0954-7894-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107274-
dc.description.abstractBACKGROUND: TNF-alpha and IL-13, two pivotal pro-inflammatory cytokines, are increased in asthmatic airways and may be linked to asthma susceptibility and/or bronchial hyperresponsiveness (BHR). OBJECTIVE: We investigated the association between the TNF-alpha-308G/A polymorphism and asthma susceptibility or asthma-related phenotypes in Korean children with asthma, and tested for a combined effect with IL-13 polymorphisms. METHODS: Asthmatic children (n=719) and non-atopic healthy control children (n=243) were evaluated for asthma phenotypes including total serum IgE and BHR to methacholine. Genotypes were determined by PCR-restriction fragment length polymorphism analysis. RESULTS: The allele frequency of TNF-alpha-308A in asthmatics (14.1%) was higher than that in control children [8.7%, odds ratio (OR) 1.72, 95% confidence interval (CI) 1.05-2.82]. Significantly lower PC(20) values were found in asthmatic children carrying one or two copies of the TNF-alpha risk allele (-308A) vs. those homozygous for the common allele (P=0.026). Combined analysis revealed that atopic asthmatic children co-inherited the risk alleles of TNF-alpha-308G/A and IL-13 +2044G/A more frequently than control children (aOR 1.91, 95% CI 1.00-3.65), and asthmatic children co-inheriting both risk alleles had significantly lower PC(20) values vs. asthmatic children homozygous for the common alleles (P=0.024). CONCLUSION: The TNF-alpha promoter polymorphism (-308G/A) may be associated with asthma susceptibility and BHR in Korean children with asthma. In addition, there appears to be a synergistic effect between the TNF-alpha promoter polymorphism and an IL-13 coding region polymorphism in terms of asthma susceptibility and BHR in this population.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL ALLERGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlleles-
dc.subject.MESHAsthma/genetics*-
dc.subject.MESHBronchial Hyperreactivity/genetics*-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-13/genetics*-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHTumor Necrosis Factor-alpha/genetics*-
dc.titleCombined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorH-B. Kim-
dc.contributor.googleauthorM-J. Kang-
dc.contributor.googleauthorS-Y. Lee-
dc.contributor.googleauthorH-S. Jin-
dc.contributor.googleauthorJ-H. Kim-
dc.contributor.googleauthorB-S. Kim-
dc.contributor.googleauthorS-O. Jang-
dc.contributor.googleauthorY-C. Lee-
dc.contributor.googleauthorM-H. Sohn-
dc.contributor.googleauthorK-E. Kim-
dc.contributor.googleauthorS-J. Hong-
dc.identifier.doi10.1111/j.1365-2222.2008.02965.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00327-
dc.contributor.localIdA01967-
dc.relation.journalcodeJ00548-
dc.identifier.eissn1365-2222-
dc.identifier.pmid18341619-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2008.02965.x-
dc.subject.keywordasthma-
dc.subject.keywordbronchial hyperresponsiveness-
dc.subject.keywordcombined effect-
dc.subject.keywordIL‐13-
dc.subject.keywordTNF‐α-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.rights.accessRightsnot available-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage774-
dc.citation.endPage780-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL ALLERGY, Vol.38(5) : 774-780, 2008-
dc.identifier.rimsid48250-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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