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Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma

 Bo Sung Yoon  ;  Young Tae Kim  ;  Sunghoon Kim  ;  Chong Seung Lee  ;  Jae Wook Kim  ;  Jae Hoon Kim  ;  Sang Wun Kim  ;  Nam Hoon Cho 
 European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol.136(1) : 110-115, 2008 
Journal Title
 European Journal of Obstetrics & Gynecology and Reproductive Biology 
Issue Date
vBiomarkers/metabolism ; Cyclin A/metabolism* ; DNA, Neoplasm/analysis* ; Female ; Flow Cytometry ; Genetic Markers ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Neoplasm Staging ; Ovarian Neoplasms/genetics* ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Ploidies* ; Prognosis ; Prospective Studies ; S Phase* ; Survival Rate
Ovarian cancer ; Prognostic factors ; DNA ploidyS-phase fractionCyclin A
OBJECTIVE: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. STUDY DESIGN: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. RESULTS: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P=0.007), more aneuploid cells (P=0.018) and higher SPF (P=0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P=0.011), the disease stage (P=0.009) and residual volume (P=0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P=0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P=0.003). CONCLUSIONS: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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