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Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma

DC Field Value Language
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재훈-
dc.contributor.author조남훈-
dc.date.accessioned2015-05-19T16:56:34Z-
dc.date.available2015-05-19T16:56:34Z-
dc.date.issued2008-
dc.identifier.issn0301-2115-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107230-
dc.description.abstractOBJECTIVE: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. STUDY DESIGN: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. RESULTS: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P=0.007), more aneuploid cells (P=0.018) and higher SPF (P=0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P=0.011), the disease stage (P=0.009) and residual volume (P=0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P=0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P=0.003). CONCLUSIONS: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent110~115-
dc.relation.isPartOfEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHvBiomarkers/metabolism-
dc.subject.MESHCyclin A/metabolism*-
dc.subject.MESHDNA, Neoplasm/analysis*-
dc.subject.MESHFemale-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHGenetic Markers-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHOvarian Neoplasms/genetics*-
dc.subject.MESHOvarian Neoplasms/metabolism-
dc.subject.MESHOvarian Neoplasms/mortality-
dc.subject.MESHPloidies*-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHS Phase*-
dc.subject.MESHSurvival Rate-
dc.titlePrognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBo Sung Yoon-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorChong Seung Lee-
dc.contributor.googleauthorJae Wook Kim-
dc.contributor.googleauthorJae Hoon Kim-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi0.1016/j.ejogrb.2006.10.008-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00595-
dc.contributor.localIdA00526-
dc.contributor.localIdA00729-
dc.contributor.localIdA00876-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ00834-
dc.identifier.eissn1872-7654-
dc.identifier.pmid17157431-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0301211506005574-
dc.subject.keywordOvarian cancer-
dc.subject.keywordPrognostic factors-
dc.subject.keywordDNA ploidyS-phase fractionCyclin A-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorKim, Jae Hoon-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume136-
dc.citation.number1-
dc.citation.startPage110-
dc.citation.endPage115-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.136(1) : 110-115, 2008-
dc.identifier.rimsid47833-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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