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Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2015-05-19T16:56:34Z | - |
dc.date.available | 2015-05-19T16:56:34Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107230 | - |
dc.description.abstract | OBJECTIVE: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. STUDY DESIGN: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. RESULTS: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P=0.007), more aneuploid cells (P=0.018) and higher SPF (P=0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P=0.011), the disease stage (P=0.009) and residual volume (P=0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P=0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P=0.003). CONCLUSIONS: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 110~115 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | vBiomarkers/metabolism | - |
dc.subject.MESH | Cyclin A/metabolism* | - |
dc.subject.MESH | DNA, Neoplasm/analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Ovarian Neoplasms/genetics* | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism | - |
dc.subject.MESH | Ovarian Neoplasms/mortality | - |
dc.subject.MESH | Ploidies* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | S Phase* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Bo Sung Yoon | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Chong Seung Lee | - |
dc.contributor.googleauthor | Jae Wook Kim | - |
dc.contributor.googleauthor | Jae Hoon Kim | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.identifier.doi | 0.1016/j.ejogrb.2006.10.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J00834 | - |
dc.identifier.eissn | 1872-7654 | - |
dc.identifier.pmid | 17157431 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0301211506005574 | - |
dc.subject.keyword | Ovarian cancer | - |
dc.subject.keyword | Prognostic factors | - |
dc.subject.keyword | DNA ploidyS-phase fractionCyclin A | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 136 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 110 | - |
dc.citation.endPage | 115 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.136(1) : 110-115, 2008 | - |
dc.identifier.rimsid | 47833 | - |
dc.type.rims | ART | - |
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