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Blockade of group II metabotropic glutamate receptors produces hyper-locomotion in cocaine pre-exposed rats by interactions with dopamine receptors.

Authors
 Hyung Shin Yoon  ;  Ju Kyong Jang  ;  Jeong-Hoon Kim 
Citation
 NEUROPHARMACOLOGY, Vol.55(4) : 555-559, 2008 
Journal Title
NEUROPHARMACOLOGY
ISSN
 0028-3908 
Issue Date
2008
MeSH
Amino Acids/adverse effects ; Animals ; Behavior, Animal/drug effects ; Benzazepines/pharmacology ; Cocaine/administration & dosage* ; Dopamine Antagonists/pharmacology ; Dopamine Uptake Inhibitors/administration & dosage* ; Dose-Response Relationship, Drug ; Drug Interactions ; Excitatory Amino Acid Antagonists/adverse effects ; Hyperkinesis/chemically induced ; Hyperkinesis/metabolism* ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine/metabolism* ; Receptors, Metabotropic Glutamate/antagonists & inhibitors ; Receptors, Metabotropic Glutamate/physiology* ; Salicylamides/pharmacology ; Xanthenes/adverse effects
Keywords
Cocaine ; LY341495 ; mGluRs ; Behavioral sensitization ; Dopamine
Abstract
It was previously reported that blockade of group II metabotropic glutamate receptors (mGluRs) produces hyper-locomotion in rats previously exposed to amphetamine, indicating that group II mGluRs are well positioned to modulate the expression of behavioral sensitization by amphetamine. The present study further examined the locomotor activating effects of specific blockade of these receptors after cocaine pre-exposures. First, rats were pre-exposed to seven daily injections of cocaine (15mg/kg, IP). When challenged the next day with an injection of either saline or the group II mGluR antagonist LY341495 (0.5, 1.0 or 2.5mg/kg, IP), they produced hyper-locomotor activity, measured by infrared beam interruptions, to LY341495 compared to saline in a dose-dependent manner. Second, rats were pre-exposed to either saline or seven daily injections of cocaine (15mg/kg, IP). Three weeks later, when they were challenged with an injection of either saline or LY341495 (1.0mg/kg, IP), only rats pre-exposed to cocaine produced hyper-locomotor activity to LY341495 compared to saline. These effects, however, were not present when dopamine D1 (SCH23390; 5 or 10microg/kg), but not D2 (eticlopride; 10 or 50microg/kg), receptor antagonist was pre-injected, indicating that this cocaine-induced hyper-locomotor activity to LY341495 may be mediated in dopamine D1 receptor-dependent manner. These results suggest that group II mGluRs may be adapted to interact with dopaminergic neuronal signaling in mediating the sensitized locomotor activity produced by repeated cocaine pre-exposures
Full Text
http://www.sciencedirect.com/science/article/pii/S002839080800289X
DOI
10.1016/j.neuropharm.2008.07.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hoon(김정훈) ORCID logo https://orcid.org/0000-0001-7095-3729
Yoon, Hyung Shin(윤형신) ORCID logo https://orcid.org/0000-0003-4389-7578
Jang, Ju Kyong(장주경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107162
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