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Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.

Authors
 Woo Jin Hyung  ;  Sung Soo Kim  ;  Won Hyuk Choi  ;  Jae Ho Cheong  ;  Seung Ho Choi  ;  Choong Bai Kim  ;  Sung Hoon Noh 
Citation
 YONSEI MEDICAL JOURNAL, Vol.49(3) : 409-415, 2008 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2008
MeSH
Age Distribution ; Aged ; Aged, 80 and over ; Female ; Gastrectomy/adverse effects ; Gastrectomy/methods* ; Gastrectomy/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Sex Distribution ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Analysis ; Survival Rate ; Treatment Outcome
Keywords
Gastric cancer ; surgery ; treatment results
Abstract
PURPOSE: Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes in long-term survival over time are not well-established. This study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a period of 45-yr. PATIENTS AND METHODS: We retrospectively evaluated 9282 patients with gastric cancer from 1955 to 1999, and divided the 45-yr into 4 time frames based on published articles: 1955 to 1962 (n=228), 1963 to 1972 (n=891), 1973 to 1988 (n=2789), and 1989 to 1999 (n=5374). RESULTS: Remarkable changes were noted in host, tumor, treatment factors, and prognosis. Among host factors, patients of more advanced age were identified in the 4th period and mean age shifted from 49 to 55 yrs. Among tumor factors, early gastric cancers and upper body tumors increased up to 32% and from 7% to 13%, respectively. An increase in the annual number of patients (from 29 to 649), gastrectomies (from 14 to 600), rate of resection (from 50% to 90%), rate of curative resection (up to 92%), and proportion of total gastrectomy (from 8% to 29%) was noted. Operative mortality was reduced from 6.1% to 0.7%. The overall 5-yr survival rate significantly increased from 22% to 65%. CONCLUSION: Treatment results of gastric cancer surgery have improved remarkably over the 45-year period. Increase of early stage gastric cancer with early diagnosis considerably influenced the improved survival of patients with gastric cancer.
Files in This Item:
T200800880.pdf Download
DOI
10.3349/ymj.2008.49.3.409
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수)
Kim, Choong Bai(김충배)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Choi, Won Hyuk(최원혁)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107156
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