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Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection

Authors
 Ji Fu Lai  ;  Sungsoo Kim  ;  Chen Li  ;  Sung Jin Oh  ;  Woo Jin Hyung  ;  Won Hyuk Choi  ;  Seung Ho Choi  ;  Lin Bo Wang  ;  Sung Hoon Noh 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.15(5) : 1464-1469, 2008 
Journal Title
ANNALS OF SURGICAL ONCOLOGY
ISSN
 1068-9265 
Issue Date
2008
MeSH
Adenocarcinoma/mortality ; Adenocarcinoma/secondary* ; Adenocarcinoma/surgery ; Adult ; Age Distribution ; Aged ; Cell Differentiation ; Female ; Humans ; Incidence ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Survival Rate
Keywords
Gastric carcinoma ; Young age ; Curative resection ; Overall survival
Abstract
BACKGROUND: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. METHODS: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. RESULTS: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). CONCLUSIONS: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.
Full Text
http://link.springer.com/article/10.1245/s10434-008-9809-1
DOI
10.1245/s10434-008-9809-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Oh, Sung Jin(오성진)
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Choi, Won Hyuk(최원혁)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107147
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