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배뇨조절과 관련된 감각세포에서 purinergic receptor와 vanilloid receptor의 분포와 상관관계

Other Titles
 Distribution of Purinergic Receptor and Vanilloid Receptor Participating in Micturition and Reciprocal Relationship between Them 
 양희준  ;  길영천  ;  이혜연 
 Korean Journal of Anatomy (대한해부학회지), Vol.41(1) : 67-72, 2008 
Journal Title
Korean Journal of Anatomy(대한해부학회지)
Issue Date
Two of the synaptic receptors involved in the regulation of micturition, P2X₃ receptor, which is operated by ATP, and vanilloid receptor 1 (VR1), which is operated by capsaicin, are regarded as newcomers. To investigate the possibility that these receptors act as therapeutic targets for treatment of an overactive bladder, we investigated their distribution and reciprocal relationship. Eight-week-old Sprague Dawley rats were injected with retrograde nerve tracer within the bladder wall, and 15 rats were injected with 0.5% acetic acid inside the bladder. After a week, the animals were killed, and their dorsal root ganglia (DRG) at the levels of L6 and S1 were harvested. Immunohistochemistry or Western blot analysis of P2X₃ and VR1 were performed on the DRG. The DRG neurons with afferent fibers from the bladder had increased expression of VR1 and downregulated P2X₃ receptors. The P2X₃ receptor and VR1 seemed to account for the important parts of the hypersensitivity of the inflammatory bladder. We conclude that the simultaneous modulations of both P2X₃ receptor and VR1 may have a synergic effect on the treatment of overactive bladder and may produce greater response rates
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Gil, Young Chun(길영천)
Yang, Hee Jun(양희준)
Lee, Hye Yeon(이혜연) ORCID logo https://orcid.org/0000-0001-6945-1967
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