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Artemin activates axonal growth via SFK and ERK-dependent signalling pathways in mature dorsal root ganglia neurons.

Authors
 Doc Gyun Jeong  ;  Wyun Kon Park  ;  Seyeon Park 
Citation
 CELL BIOCHEMISTRY AND FUNCTION, Vol.26(2) : 210-220, 2008 
Journal Title
 CELL BIOCHEMISTRY AND FUNCTION 
ISSN
 0263-6484 
Issue Date
2008
MeSH
Actins/metabolism ; Animals ; Axons/drug effects ; Axons/metabolism* ; Cells, Cultured ; Extracellular Signal-Regulated MAP Kinases/metabolism* ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism* ; Humans ; Mitogen-Activated Protein Kinases/metabolism ; Nerve Tissue Proteins/pharmacology ; Nerve Tissue Proteins/physiology* ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism* ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; src Homology Domains/physiology ; src-Family Kinases/metabolism*
Keywords
artemin ; axonal growth ; src-family kinase ; ERK ; SH3 binding partner
Abstract
Artemin, one of the glial cell line-derived neurotrophic factor (GDNF) family, enhances the generation and survival of early sympathetic neurons and superior cervical ganglion (SCG) neurons. Src-family kinases (SFK) are involved in the growth and differentiation of cells, which are composed of unique Src homology 2 (SH2), Src homology 3 (SH3) and kinase domains. Various extra-cellular molecules containing growth factors and G-protein coupled receptors stimulate SFK. In this report, artemin is shown to have a significant effect on the neurite growth of dorsal root ganglia (DRG) neurons. Also, artemin triggers Src-family kinase activation and the phosphorylation of extra-cellular signal-regulated kinases (ERK) mitogen-activated protein kinase (MAPK). Artemin also regulated actin polymerization. There are several indications that another SH3-containing protein, Hck, and an SH3-containing adaptor protein, Nck1, play an important role in the organization of the actin cytoskeleton by cellular signalling. These findings suggest that the exploration of binding partners for the SH3 domain could provide an insight into regulation between the microtubule and actin networks. The binding partners for the SH3 domains of Nck, Src and Hck that we identified were Smc chromosome segregation ATPases, FOG Zn-finger protein and the FYVE zinc-binding domain, respectively
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/cbf.1436/abstract
DOI
10.1002/cbf.1436
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Park, Wyun Kon(박윤곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107096
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