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The duration of intrathecal bupivacaine mixed with lidocaine

Authors
 Sung-Jin Lee  ;  Sun-Joon Bai  ;  Jong-Seok Lee  ;  Won-Ok Kim  ;  Yang-Sik Shin  ;  Ki-Young Lee 
Citation
 ANESTHESIA AND ANALGESIA, Vol.107(3) : 824-827, 2008 
Journal Title
 ANESTHESIA AND ANALGESIA 
ISSN
 0003-2999 
Issue Date
2008
MeSH
Aged ; Anesthetics, Local/administration & dosage* ; Bupivacaine/administration & dosage* ; Double-Blind Method ; Drug Synergism* ; Female ; Humans ; Injections, Spinal ; Lidocaine/administration & dosage* ; Male ; Middle Aged ; Polypharmacy ; Prostatic Neoplasms/surgery* ; Time Factors ; Urinary Bladder Neoplasms/surgery*
Keywords
Aged ; Anesthetics, Local/administration & dosage* ; Bupivacaine/administration & dosage* ; Double-Blind Method ; Drug Synergism* ; Female ; Humans ; Injections, Spinal ; Lidocaine/administration & dosage* ; Male ; Middle Aged ; Polypharmacy ; Prostatic Neoplasms/surgery* ; Time Factors ; Urinary Bladder Neoplasms/surgery*
Abstract
BACKGROUND: Although spinal bupivacaine may have too long duration to be useful in the ambulatory setting, recent animal data suggest that lidocaine added to spinal bupivacaine may reduce the duration of bupivacaine spinal anesthesia. We explored whether lidocaine added to spinal bupivacaine could shorten the duration of bupivacaine spinal anesthesia in humans similarly to what has been reported in animals. METHODS: Ninety patients presenting for transurethral resection of bladder tumor or prostate were assigned to one of three groups by double blind randomization to receive intrathecal 1.5 mL of hyperbaric 0.5% bupivacaine, plus 0.6 mL of one of three solutions: saline (Group I, n = 30, control), 1% lidocaine (Group II, n = 30), and 2% lidocaine (Group III, n = 30). Peak sensory block level, time to peak sensory block, times to two-segment, L1, and S2 regressions from peak sensory block, motor blocks at peak sensory block, L1, and S2 regressions, and postanesthesia care unit stay time (PACU time) were measured. RESULTS: Times to peak sensory block were similar in all three groups. Times to two-segment, L1, and S2 regressions from peak sensory block, and PACU time were significantly reduced in Group II compared to Group I. Times to L1, S2 regressions, and PACU times in Group III were significantly prolonged. CONCLUSIONS: We conclude that lidocaine (6 mg) mixed to spinal bupivacaine (7.5 mg) can shorten the duration of bupivacaine spinal anesthesia, therefore provide more rapid recovery from the spinal anesthesia compared to the same dose of bupivacaine (7.5 mg) alone.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000539-200809000-00019&LSLINK=80&D=ovft
DOI
10.1213/ane.0b013e3181806149
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Oak(김원옥)
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Shin, Yang Sik(신양식)
Lee, Ki Young(이기영) ORCID logo https://orcid.org/0000-0003-4893-3195
Lee, Sung Jin(이성진)
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107095
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