Cited 23 times in
Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동익 | - |
dc.contributor.author | 김동준 | - |
dc.contributor.author | 김진아 | - |
dc.contributor.author | 이승구 | - |
dc.date.accessioned | 2015-05-19T16:49:57Z | - |
dc.date.available | 2015-05-19T16:49:57Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107026 | - |
dc.description.abstract | BACKGROUND: Acute inflammatory responses have been thought to play a central role in ischemia-reperfusion injury after acute ischemic stroke. Superparamagnetic iron oxide (SPIO) particles have been known to enable in-vivo monitoring of macrophage infiltration by magnetic resonance imaging (MRI) in the experimental ischemic rat brain. PURPOSE: To determine whether the accumulation of macrophages could be seen in vivo in a reperfusion animal model after focal cerebral ischemia using SPIO-enhanced MRI. MATERIAL AND METHODS: Thirty-four adult male rats were enrolled in this study. SPIO particles were injected into the rats at different time points after 1-hour transient occlusion of the middle cerebral artery, and three-dimensional (3D) T2*-weighted magnetic resonance (MR) images with a gradient-echo sequence were performed 24 hours later. Histochemical iron staining was compared with T2* signal abnormalities. RESULTS: At days 3 and 4 post-reperfusion, focal areas of signal loss indicating local accumulation of SPIO particles appeared in a part of the damaged brain. Areas of signal loss corresponded to local accumulation of iron-laden macrophages in histologic sections, and SPIO-induced signal loss indicated active macrophage transmigration into the reperfused brain. CONCLUSION: SPIO-enhanced MRI demonstrated through in-vivo monitoring that macrophages participate in reperfusion injury at early stages of injury development. SPIO-enhanced MRI could be a useful tool to examine the inflammatory mechanisms involved in reperfusion brain injury. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 580~588 | - |
dc.relation.isPartOf | ACTA RADIOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Brain/ultrastructure | - |
dc.subject.MESH | Contrast Media/administration & dosage | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Ferrosoferric Oxide* | - |
dc.subject.MESH | Image Enhancement/methods* | - |
dc.subject.MESH | Imaging, Three-Dimensional | - |
dc.subject.MESH | Inflammation/diagnosis* | - |
dc.subject.MESH | Inflammation/etiology | - |
dc.subject.MESH | Ischemic Attack, Transient/complications | - |
dc.subject.MESH | Ischemic Attack, Transient/diagnosis* | - |
dc.subject.MESH | Macrophages/pathology | - |
dc.subject.MESH | Macrophages/ultrastructure | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reperfusion Injury/diagnosis* | - |
dc.subject.MESH | Reperfusion Injury/etiology | - |
dc.subject.MESH | Time Factors | - |
dc.title | Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Kim J | - |
dc.contributor.googleauthor | Kim D | - |
dc.contributor.googleauthor | Lee SK | - |
dc.contributor.googleauthor | Kim DJ | - |
dc.contributor.googleauthor | Lee JE | - |
dc.contributor.googleauthor | Ahn SK. | - |
dc.identifier.doi | 10.1080/02841850802020484 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01022 | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A02912 | - |
dc.relation.journalcode | J00033 | - |
dc.identifier.eissn | 1600-0455 | - |
dc.identifier.pmid | 18568546 | - |
dc.identifier.url | http://acr.sagepub.com/content/49/5/580.abstract | - |
dc.subject.keyword | Acute ischemic stroke | - |
dc.subject.keyword | contrast media | - |
dc.subject.keyword | ferucarbotran | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | macrophage | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | reperfusion | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.alternativeName | Kim, Jinna | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Kim, Jinna | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 580 | - |
dc.citation.endPage | 588 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, Vol.49(5) : 580-588, 2008 | - |
dc.identifier.rimsid | 49476 | - |
dc.type.rims | ART | - |
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