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Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy

 Heekyoung Choi  ;  Su Jin Jeong  ;  Han Sung Lee  ;  Bum Sik Chin  ;  Suk Hoon Choi  ;  Sang Hoon Han  ;  Myung Soo Kim  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
 Journal of Korean Medical Science, Vol.23(4) : 737-739, 2008 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adult ; Atazanavir Sulfate ; Drug Resistance, Multiple, Viral ; Drug Therapy, Combination ; HIV Infections/drug therapy* ; HIV Protease Inhibitors/administration & dosage* ; Humans ; Lopinavir ; Male ; Oligopeptides/administration & dosage* ; Pyridines/administration & dosage* ; Pyrimidinones/administration & dosage* ; Ritonavir/administration & dosage*
Double-Boosted Protease Inhibitor Therapy ; Atazanavir ; Lopinavir ; Salvage Therapy ; HIV Infections
The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Suk Hoon(최석훈)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
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