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Quantitative Assessment of Synovial Vascularity Using Contrast-Enhanced Power Doppler Ultrasonography: Correlation with Histologic Findings and MR Imaging Findings in Arthritic Rabbit Knee Model
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.date.accessioned | 2015-05-19T16:47:32Z | - |
dc.date.available | 2015-05-19T16:47:32Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106953 | - |
dc.description.abstract | OBJECTIVE: To validate contrast-enhanced power Doppler ultrasonography (PD US) for the evaluation of synovial vascularity in an arthritic rabbit knee model in correlation with MR and histological findings.0aMATERIALS AND METHODS: Power Doppler ultrasonography was performed for carrageenin-induced arthritic left knee and control right knee of 13 rabbits, first without and then with sonic contrast agent enhancement (Levovist, Schering, Berlin Germany), followed by gadolinium-enhanced MR imaging. Synovial vascularity was quantitatively assessed by calculating the color pixel area in power Doppler sonography using a computer-aided image analysis program and by grading the enhancement on MR images: grade 1, enhancement of knee joint is less than one-third of the area; grade 2, one-third to two-thirds enhancement; and grade 3, more than two-thirds enhancement. Microvessel density (MVD) was measured on slides stained immunohistochemically for CD31 antigen for histological assessment.0aRESULTS: The mean area of color pixels in PD US changed from 4.37 to 16.42 mm2 in the arthritic knee after enhancement (p < 0.05), whereas it changed from 0.77 to 2.31 mm2 in the control knee (p < 0.05). Arthritic knees had greater power Doppler signal than control knees both before and after contrast administration (p < 0.05). The average MVD was 88 in arthritic knees and 46 in control knees. MVDs correlated with color pixel areas of contrast-enhanced power Doppler imaging in arthritic knees. In MR grading of arthritic knees, five were grade 2 and eight were grade 3. MVD and PD US revealed no significant difference between grade 2 and 3 arthritic knees (p > 0.05).0aCONCLUSION: Sonic contrast-enhanced PD US improves the visualization of synovial vascularity and allows quantitative measurement in experimentally induced rabbit arthritic knees. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 45~53 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Gadolinium DTPA | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Osteoarthritis, Knee/diagnostic imaging* | - |
dc.subject.MESH | Osteoarthritis, Knee/pathology | - |
dc.subject.MESH | Polysaccharides | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Synovial Membrane/blood supply* | - |
dc.subject.MESH | Synovial Membrane/diagnostic imaging | - |
dc.subject.MESH | Synovial Membrane/pathology | - |
dc.subject.MESH | Ultrasonography, Doppler* | - |
dc.title | Quantitative Assessment of Synovial Vascularity Using Contrast-Enhanced Power Doppler Ultrasonography: Correlation with Histologic Findings and MR Imaging Findings in Arthritic Rabbit Knee Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Myung Jin Shin | - |
dc.contributor.googleauthor | Seong Moon Kim | - |
dc.contributor.googleauthor | Namkug Kim | - |
dc.contributor.googleauthor | Sang Hyun Suh | - |
dc.identifier.doi | 10.3348/kjr.2008.9.1.45 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 18253075 | - |
dc.subject.keyword | Arthritis | - |
dc.subject.keyword | Joints | - |
dc.subject.keyword | US | - |
dc.subject.keyword | Synovitis | - |
dc.subject.keyword | Ultrasound (US) | - |
dc.subject.keyword | Power Doppler studies | - |
dc.subject.keyword | Magnetic resonance (MR) | - |
dc.subject.keyword | Arthrtis | - |
dc.subject.keyword | animal studies | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 53 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.9(1) : 45-53, 2008 | - |
dc.identifier.rimsid | 56394 | - |
dc.type.rims | ART | - |
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