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Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Authors
 Yumie Rhee  ;  Man-Jeong Paik  ;  Kyoung-Rae Kim  ;  Young-Guk Ko  ;  Eun Seok Kang  ;  Bong Soo Cha  ;  Hyun Chul Lee  ;  Sung-Kil Lim 
Citation
 CLINICA CHIMICA ACTA, Vol.392(1-2) : 11-16, 2008 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2008
MeSH
Adult ; Aged ; Body Mass Index ; Coronary Disease/etiology* ; Fatty Acids, Nonesterified/blood* ; Fatty Acids, Unsaturated/blood* ; Female ; Humans ; Korea ; Middle Aged ; Organic Chemicals ; Postmenopause/blood* ; Risk Factors
Keywords
Polyunsaturated fatty acid ; Menopause ; Diabetes mellitus ; Coronary heart disease
Abstract
BACKGROUND: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. METHODS: The participants were as follows; premenopausal women (PRE, n=20) and postmenopausal women without any known chronic disease (POST, n=35), with DM (DM, n=35), or with angiographically proven CHD (CHD, n=30). Plasma free fatty acids were measured in all participants. RESULTS: Healthy premenopausal women had a higher ratio of omega-3/omega-6 PUFA than postmenopausal women (p=0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p<0.05) and lower arachidonic acid levels (p<0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p<0.05). There were significant shifts of increased omega-6 and decreased omega-3 among the women, according to each disease. CONCLUSIONS: There was a significant relationship between omega-3 and omega-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898108000776
DOI
10.1016/j.cca.2008.02.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106951
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