129 285

Cited 27 times in

Zeatin supplement improves scopolamine-induced memory impairment in mice

Authors
 Mi Jeong KIM  ;  Soo Jung CHOI  ;  Seung-Taik LIM  ;  Hye Kyung KIM  ;  Young Jun KIM  ;  Ho-Geun YOON  ;  Dong-Hoon SHIN 
Citation
 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.72(2) : 577-581, 2008 
Journal Title
 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 
ISSN
 0916-8451 
Issue Date
2008
MeSH
Animals ; Cholinergic Antagonists/adverse effects* ; Memory Disorders/prevention & control* ; Mice ; Scopolamine Hydrobromide/adverse effects* ; Zeatin/administration & dosage ; Zeatin/pharmacology*
Keywords
acetylcholinesterase ; cognitive function ; zeatin [6-(4-hydroxy-3-methyl-trans-2-butenylamino) purine] ; scopolamine ; Alzheimer’s disease
Abstract
In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.
Files in This Item:
T200800659.pdf Download
DOI
10.1271/bbb.70480
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106904
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse