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Influence of topical bimatoprost on macular thickness and volume in glaucoma patients with phakic eyes

Authors
 Ho Yeop Yeom  ;  Samin Hong  ;  Sung Soo Kim  ;  Chan Yun Kim  ;  Gong Je Seong 
Citation
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, Vol.43(5) : 563-566, 2008 
Journal Title
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE 
ISSN
 0008-4182 
Issue Date
2008
MeSH
Administration, Topical ; Amides/administration & dosage* ; Antihypertensive Agents/administration & dosage* ; Bimatoprost ; Body Weights and Measures ; Cloprostenol/administration & dosage ; Cloprostenol/analogs & derivatives* ; Contrast Sensitivity/drug effects ; Female ; Glaucoma, Open-Angle/drug therapy* ; Humans ; Intraocular Pressure/drug effects* ; Lens, Crystalline/physiology* ; Macula Lutea/anatomy & histology ; Macula Lutea/drug effects* ; Male ; Middle Aged ; Tomography, Optical Coherence ; Visual Acuity/drug effects
Keywords
bimatoprost ; glaucoma ; macular thickness ; optical coherence tomography
Abstract
BACKGROUND: In light of concern about the possible relation between the extensive clinical use of prostaglandin analogues and the development of retinal disorders such as cystoid macular edema, this study investigated the influence of topical application of bimatoprost 0.03% on macular thickness and volume in glaucoma patients with phakic eyes. METHODS: A total of 40 eyes in 22 patients with primary open-angle glaucoma or normal-tension glaucoma were evaluated in this study. Optical coherence tomography images were taken before initiation of bimatoprost application and after 1, 2, and 3 months of treatment. In addition, best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were measured, and contrast sensitivity tests and fundus examinations were performed. Changes in various parameters, including macular thickness and volume, were analyzed. RESULTS: BCVA and contrast sensitivity did not change from baseline over the treatment period. IOP declined by 20% to 25% from baseline for 1 month before stabilizing. Macular thickness and volume did not increase significantly during the 3 months. INTERPRETATION: Topical application of bimatoprost does not induce clinical or structural changes in the macula, at least in glaucoma patients with phakic eyes. Moreover, bimatoprost effectively lowered IOP without causing macular disorders such as cystoid macular edema.
Full Text
http://www.sciencedirect.com/science/article/pii/S000841820880083X
DOI
10.3129/i08-092
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106886
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