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A polyethylene glycol grafted bi-layered polyurethane scaffold: preliminary study of a new candidate prosthesis for repair of a partial tracheal defect

Authors
 Hong-Shik Choi  ;  Hwal Suh  ;  Ja-Hyun Lee  ;  Si-Nae Park  ;  Sang-Hyun Shin  ;  Young-Ho Kim  ;  Sung Min Chung  ;  Hyun Kyung Kim  ;  Jae-Yol Lim  ;  Han Su Kim 
Citation
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.265(7) : 809-816, 2008 
Journal Title
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 
ISSN
 0937-4477 
Issue Date
2008
MeSH
Animals ; Bioprosthesis* ; Dogs ; Endoscopy ; Granulation Tissue ; Polyethylene Glycols/therapeutic use* ; Polyurethanes/therapeutic use* ; Respiratory Mucosa/pathology ; Trachea/injuries* ; Trachea/surgery ; Tracheal Neoplasms/surgery*
Keywords
Tracheal prosthesis ; Polyethylene ; Polyurethane
Abstract
The purpose of this study was to develop an artificial prosthesis for use in the reconstruction of a tracheal defect due to trauma, malignancy, stenosis, or other causes. Bi-layered porous-dense film polyurethane (PU) was manufactured for the main framework. Polyethylene glycol (PEG) was grafted onto the inner surface of the PU scaffold to act as a surfactant. The scaffold was transplanted into three beagles. An endoscopic examination was performed for the evaluation of the formation granulation tissue, to evaluate the status of the respiratory mucosa and the amount of crust at 1, 4, 8, and 12 weeks after surgery. A histological examination was also performed at 4, 8, and 12 weeks after surgery. All three beagles studied survived to the expected date. The endoscopic examination showed formation of granulation tissue; the crust was not very severe and the circular tracheal framework was well preserved. The histological examination showed that a large amount of fibrous tissue had grown through the pores of the porous scaffold. Pseudostratified columnar ciliated mucosa was also noted on the surface of scaffold, as visualized by scanning electron microscopy. The use of a bi-layered polyethylene grafted polyurethane scaffold is a good candidate prosthesis for tracheal reconstruction
Full Text
http://link.springer.com/article/10.1007%2Fs00405-007-0574-8
DOI
10.1007/s00405-007-0574-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Ho(김영호)
Park, Si Nae(박시내)
Suh, Hwal(서활)
Shin, Sang Hyun(신상현)
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Hong Shik(최홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106866
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