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Effect of geometric remodeling on left ventricular longitudinal contractile reserve in patients with hypertension

Authors
 Sungha Park  ;  Hye-Sun Seo  ;  Chi Young Shim  ;  Eui Young Choi  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Jong-Won Ha  ;  Se-Joong Rim  ;  Namsik Chung 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol.21(3) : 246-250, 2008 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 
ISSN
 0894-7317 
Issue Date
2008
MeSH
Coronary Circulation ; Exercise Test ; Female ; Fractional Flow Reserve, Myocardial* ; Humans ; Hypertension/complications* ; Hypertension/diagnostic imaging* ; Hypertrophy, Left Ventricular/diagnostic imaging* ; Hypertrophy, Left Ventricular/etiology* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasonography ; Ventricular Dysfunction, Left/diagnostic imaging* ; Ventricular Dysfunction, Left/etiology* ; Ventricular Remodeling
Keywords
Coronary Circulation ; Exercise Test ; Female ; Fractional Flow Reserve, Myocardial* ; Humans ; Hypertension/complications* ; Hypertension/diagnostic imaging* ; Hypertrophy, Left Ventricular/diagnostic imaging* ; Hypertrophy, Left Ventricular/etiology* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasonography ; Ventricular Dysfunction, Left/diagnostic imaging* ; Ventricular Dysfunction, Left/etiology* ; Ventricular Remodeling
Abstract
Left ventricular hypertrophy (LVH) is associated with a reduction of subendocardial coronary flow reserve, which may be associated with abnormal myocardial longitudinal function during exercise. To test this hypothesis, 182 hypertensive patients underwent multistage supine bicycle exercise testing. Patients were classified as follows: patients with normal geometry (group 1, n = 116), concentric remodeling (group 2, n = 31), or LVH (group 3, n = 31). The results showed that the ratio of E/E', an index of left ventricular (LV) filling pressure, was significantly elevated in the LVH group at rest and during exercise. At rest, the mitral annular systolic velocity (S') was similar between the three groups at rest, whereas S' during exercise was significantly lower in the LVH group. The magnitude of change in S' during exercise was also significantly lower in the LVH group. Multiple linear regression analysis showed that peak double product (beta = 0.208, P = .006) and LV mass index (beta = -0.158, P = .028) were independently associated with LV longitudinal contractile reserve. Also, multiple linear regression analysis showed that changes in S' from baseline to peak were independently associated with exercise duration (beta = 0.123, P = .041) when controlled for age, male gender, baseline E', peak systolic blood pressure, and LV mass index. The results from this study demonstrate that LVH was significantly associated with abnormal LV longitudinal contractile reserve in hypertensive patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0894731707004774
DOI
10.1016/j.echo.2007.06.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Seo, Hye Sun(서혜선)
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106847
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