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Macrophage migration inhibitory factor may be used as an early diagnostic marker in colorectal carcinomas

Authors
 Hanna Lee  ;  Hwanseok Rhee  ;  Hyun Ju Kang  ;  Hyon-Suk Kim  ;  Byung Soh Min  ;  Nam Kyu Kim  ;  Hoguen Kim 
Citation
 AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol.129(5) : 772-779, 2008 
Journal Title
 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 
ISSN
 0002-9173 
Issue Date
2008
MeSH
• Area Under Curve ; Biomarkers, Tumor/blood* ; Carcinoembryonic Antigen/blood ; Colorectal Neoplasms/blood* ; Colorectal Neoplasms/diagnosis* ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Female ; Gene Expression ; Humans ; Macrophage Migration-Inhibitory Factors/blood* ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; ROC Curve ; Sensitivity and Specificity
Keywords
Colorectal carcinoma ; Macrophage migration inhibitory factor ; MIF ; Gene expression profile ; Diagnostic biomarker
Abstract
Recent genetic studies have identified many differentially expressed genes in colorectal carcinomas. For validation of up-regulated genes in colorectal carcinomas, we performed an enzyme-linked immunosorbent assay. Candidate markers were selected from gene expression data for 40 colorectal cancers and 35 matched normal mucosal samples. Based on intensive filtering, 9 genes were selected for the further evaluations. Among them, macrophage migration inhibitory factor (MIF), inhibin betaA, and chemokine ligand 10 were screened, and the results were compared with carcinoembryonic antigen (CEA) in serum samples of 129 patients with colon cancer and 53 healthy control subjects. We found that the serum MIF level was significantly increased in patients with colorectal cancer. Compared with CEA, MIF was more sensitive in early cancer detection (47.3% vs 29.5%). However, the specificity was not as high as that of CEA (90.6% vs 100.0%). Our findings indicate that MIF may be used as a diagnostic marker in colorectal carcinomas
Files in This Item:
T200800584.pdf Download
DOI
10.1309/GFCLLRH8A68XKMJN
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Clinical Genetics (임상유전학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Ju(강현주)
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Hyon Suk(김현석)
Kim, Ho Keun(김호근)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Lee, Hanna(이한나)
Rhee, Hwan Seok(이환석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106804
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