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MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Authors
 Young Joon Yoon  ;  Hye Young Chang  ;  Sang Hoon Ahn  ;  Ja Kyung Kim  ;  Yong Kwang Park  ;  Dae Ryong Kang  ;  Jun Yong Park  ;  Sung Min Myoung  ;  Do Young Kim  ;  Chae Yoon Chon  ;  Kwang-Hyub Han 
Citation
 CARCINOGENESIS, Vol.29(6) : 1192-1196, 2008 
Journal Title
 CARCINOGENESIS 
ISSN
 0143-3334 
Issue Date
2008
MeSH
• Age of Onset ; Carcinoma, Hepatocellular/genetics* ; Carcinoma, Hepatocellular/virology ; Female ; Genes, p53/genetics* ; Genetic Predisposition to Disease* ; Genotype ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/genetics ; Humans ; Korea ; Liver Neoplasms/genetics* ; Liver Neoplasms/virology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-mdm2/genetics*
Keywords
• Age of Onset ; Carcinoma, Hepatocellular/genetics* ; Carcinoma, Hepatocellular/virology ; Female ; Genes, p53/genetics* ; Genetic Predisposition to Disease* ; Genotype ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/genetics ; Humans ; Korea ; Liver Neoplasms/genetics* ; Liver Neoplasms/virology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-mdm2/genetics*
Abstract
A single-nucleotide polymorphism (SNP) in the promoter region of MDM2, SNP 309, is associated with hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus infection. The effect of p53 codon 72 polymorphism Arg72Pro on HCC risk remains inconsistent. This study evaluated the association of MDM2 and p53 polymorphisms with the presence and early onset of HCC in Korean patients with chronic hepatitis B virus (HBV) infection. In total, 583 consecutive patients with chronic HBV infection were classified according to the presence (n = 287) or absence (n = 296) of HCC. The MDM2 SNP 309 and p53 Arg72Pro were genotyped using restriction fragment length polymorphism method. The MDM2 G/G and p53 Pro/Pro genotypes were more frequent in HCC group than in non-HCC group (P < 0.001 and P = 0.004, respectively). Multivariate analysis for the presence of HCC revealed that the odds ratio (OR) for MDM2 G/G over T/T was 4.89 (P < 0.001) and that of p53 Pro/Pro over Arg/Arg was 3.03 (P = 0.006). Combined MDM2 G/G and p53 Pro/Pro had a synergistic effect on HCC risk, with an OR of 20.78 (P < 0.001). The mean age of tumor onset in patients with MDM2 G/G genotype was 50.9 years compared with 55.1 with T/T genotype (P = 0.018) and that with p53 Pro/Pro was 49.7 years compared with 52.9 with Arg/Arg (P = 0.040). Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
Files in This Item:
T200800582.pdf Download
DOI
10.1093/carcin/bgn090
Appears in Collections:
5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Myung, Sung Min(명성민)
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yoon, Young Joon(윤영준)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106802
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