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Effects of increasing particle size of low-density lipoprotein on restenosis after coronary stent implantation

 Jung-Sun Kim  ;  Myung-Hyun Kim  ;  Byoung Kwon Lee  ;  Se-Joong Rim  ;  Pil-Ki Min  ;  Se-Jung Yoon  ;  Jeong-Ho Kim  ;  Ji-Hyuck Rhee  ;  Young Won Yoon  ;  Bum Kee Hong  ;  Hyuck Moon Kwon  ;  Changsoo Kim 
 CIRCULATION JOURNAL, Vol.72(7) : 1059-1064, 2008 
Journal Title
Issue Date
Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/metabolism ; Aged ; Angioplasty, Balloon, Coronary* ; Coronary Angiography ; Coronary Restenosis/diagnostic imaging ; Coronary Restenosis/epidemiology* ; Coronary Restenosis/metabolism* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lipoproteins, LDL/blood* ; Lipoproteins, LDL/chemistry ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Particle Size ; Predictive Value of Tests ; Risk Factors ; Stents*
Coronary stent ; Restenosis ; Small dense low-density lipoprotein
BACKGROUND: Small dense low-density lipoprotein (LDL) has emerged as an important risk factor in coronary atherosclerosis and vascular inflammation, which is related to neointimal hyperplasia. Therefore, the aim of the present study was to investigate whether changes in LDL particle size are related to in-stent restenosis (ISR). METHODS AND RESULTS: The LDL subfraction and lipid profiles were measured in 274 patients (412 stents) at both baseline and follow-up coronary angiography (CAG). The incidence of ISR (80 lesions, 19.4%) was lower in the patients with increased LDL particle size than in those with no change or decrease (14.2% vs 25.8%, p=0.004). Logistic multivariate analysis revealed that stent length (>or=24 mm) (odds ratio (OR) =1.913, p=0.027), post minimal luminal diameter (>3 mm) (OR =0.528, p=0.028), acute coronary syndrome (OR =2.294, p=0.005), decrease in high-density lipoprotein-cholesterol (OR =1.028, p=0.047) and increase in LDL particle size (OR =0.528, p=0.031) were independent predictors for ISR. CONCLUSIONS: In the present study, an increase in the LDL particle size between baseline and follow-up CAG was associated with reduced incidence of ISR. Therefore, modification of LDL particle size may have a beneficial effect on the risk of ISR
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Yoon, Se Jung(윤세정)
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Rhee, Ji Hyuk(이지혁)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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