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Effects of increasing particle size of low-density lipoprotein on restenosis after coronary stent implantation

 Jung-Sun Kim  ;  Myung-Hyun Kim  ;  Byoung Kwon Lee  ;  Se-Joong Rim  ;  Pil-Ki Min  ;  Se-Jung Yoon  ;  Jeong-Ho Kim  ;  Ji-Hyuck Rhee  ;  Young Won Yoon  ;  Bum Kee Hong  ;  Hyuck Moon Kwon  ;  Changsoo Kim 
 Circulation Journal, Vol.72(7) : 1059-1064, 2008 
Journal Title
 Circulation Journal 
Issue Date
BACKGROUND: Small dense low-density lipoprotein (LDL) has emerged as an important risk factor in coronary atherosclerosis and vascular inflammation, which is related to neointimal hyperplasia. Therefore, the aim of the present study was to investigate whether changes in LDL particle size are related to in-stent restenosis (ISR). METHODS AND RESULTS: The LDL subfraction and lipid profiles were measured in 274 patients (412 stents) at both baseline and follow-up coronary angiography (CAG). The incidence of ISR (80 lesions, 19.4%) was lower in the patients with increased LDL particle size than in those with no change or decrease (14.2% vs 25.8%, p=0.004). Logistic multivariate analysis revealed that stent length (>or=24 mm) (odds ratio (OR) =1.913, p=0.027), post minimal luminal diameter (>3 mm) (OR =0.528, p=0.028), acute coronary syndrome (OR =2.294, p=0.005), decrease in high-density lipoprotein-cholesterol (OR =1.028, p=0.047) and increase in LDL particle size (OR =0.528, p=0.031) were independent predictors for ISR. CONCLUSIONS: In the present study, an increase in the LDL particle size between baseline and follow-up CAG was associated with reduced incidence of ISR. Therefore, modification of LDL particle size may have a beneficial effect on the risk of ISR
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
김정호(Kim, Jeong Ho) ORCID logo https://orcid.org/0000-0003-2479-0548
김중선(Kim, Jung Sun) ORCID logo https://orcid.org/0000-0003-2263-3274
김창수(Kim, Chang Soo) ORCID logo https://orcid.org/0000-0002-5940-5649
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
윤세정(Yoon, Se Jung)
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이지혁(Rhee, Ji Hyuk)
임세중(Rim, Se Joong) ORCID logo https://orcid.org/0000-0002-7631-5581
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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