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A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

Authors
 EUN SEOK KANG  ;  MYOUNG SOO KIM  ;  YU SEUN KIM  ;  KYU YEON HUR  ;  SEUNG JIN HAN  ;  CHUNG MO NAM  ;  CHUL WOO AHN  ;  BONG SOO CHA  ;  SOON IL KIM  ;  HYUN CHUL LEE 
Citation
 DIABETES CARE, Vol.31(1) : 63-68, 2008 
Journal Title
 DIABETES CARE 
ISSN
 0149-5992 
Issue Date
2008
MeSH
Adult ; Body Weight ; DNA/blood ; DNA/genetics ; DNA/isolation & purification ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics* ; Drug Therapy, Combination ; Female ; Genetic Variation* ; Genotype ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects* ; Kidney Transplantation/immunology ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Retrospective Studies ; Risk Factors ; TCF Transcription Factors/genetics* ; Transcription Factor 7-Like 2 Protein ; Transplantation, Homologous/adverse effects
Keywords
Adult ; Body Weight ; DNA/blood ; DNA/genetics ; DNA/isolation & purification ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics* ; Drug Therapy, Combination ; Female ; Genetic Variation* ; Genotype ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects* ; Kidney Transplantation/immunology ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Retrospective Studies ; Risk Factors ; TCF Transcription Factors/genetics* ; Transcription Factor 7-Like 2 Protein ; Transplantation, Homologous/adverse effects
Abstract
OBJECTIVE: Posttransplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene was reported to be associated with type 2 diabetes and possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2 and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS: A total of 511 unrelated renal allograft recipients without previously known diabetes were enrolled. Six single nucleotide polymorphisms (rs11196205, rs4506565, rs12243326, rs7903146, rs12255372, and rs7901695) were genotyped in the cohort, which consisted of 119 PTDM patients and 392 non-PTDM subjects. The genotyping of TCF7L2 polymorphisms was performed using real-time PCR. RESULTS: rs4506565, rs7901695, and rs7903146 were found to be in complete linkage disequilibrium. The rs7903146 genotype distribution was CC 94.3% and CT 5.7%. The incidence of PTDM was significantly higher in patients with the CT genotype than in patients with the CC genotype (41.4 vs. 22.2%) (odds ratio 2.474 [95% CI 1.146-5.341]; P = 0.024). The effect of this genotype remains significant after adjustment for age, sex, amount of body weight gain, and type of immunosuppressant (2.655 [1.168-6.038]; P = 0.020). CONCLUSIONS: These data suggest that the TCF7L2 rs7903146 genetic variation is associated with an increased risk of PTDM in renal allograft recipients.
Full Text
http://care.diabetesjournals.org/content/31/1/63
DOI
10.2337/dc07-1005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Seung Jin(한승진)
Hur, Kyu Yeon(허규연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106742
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