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LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients

Authors
 Eun Seok Kang  ;  Se Eun Park  ;  Seung Jin Han  ;  So Hun Kim  ;  Chung Mo Nam  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Kyung Sub Kim  ;  Hyun Chul Lee 
Citation
 MOLECULAR GENETICS AND METABOLISM, Vol.95(1-2) : 96-100, 2008 
Journal Title
MOLECULAR GENETICS AND METABOLISM
ISSN
 1096-7192 
Issue Date
2008
MeSH
Blood Glucose/analysis ; Cohort Studies ; Diabetes Mellitus, Type 2/drug therapy* ; Diabetes Mellitus, Type 2/genetics* ; Diabetes Mellitus, Type 2/metabolism ; Female ; Genetic Variation* ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/administration & dosage* ; Linkage Disequilibrium ; Male ; Middle Aged ; Nuclear Proteins/genetics* ; Nuclear Proteins/metabolism ; Phosphatidate Phosphatase ; Polymorphism, Single Nucleotide ; Thiazolidinediones/administration & dosage*
Keywords
Genetic association ; Lipin ; SNP ; Rosiglitazone ; Type 2 diabetes ; Pharmacogenetics
Abstract
Lipin1 protein, a product of the LPIN1 gene, is required for normal adipose tissue development and metabolism. Lipin1 deficiency results in immature adipocyte development in cases of mouse fatty liver dystrophy and human lipodystrophy. Recently, pioglitazone has been reported to increase human adipocyte lipin1 expression. We evaluated the effects of LPIN1 polymorphisms on rosiglitazone response in patients with type 2 diabetes (T2DM). A total of 262 patients were treated with 12 weeks of rosiglitazone (4 mg/day) in addition to their previous drug regimen medications. Six single nucleotide polymorphisms (SNPs) at the LPIN1 locus were genotyped: rs11693809, rs10192566, rs2278513, rs2577262, rs2716610, and rs1050800. Because rs11693809, rs10192566, and rs2278513 are in nearly complete linkage disequilibrium (D'>0.958, r(2) >0.882), we analyzed rs10192566, rs2577262, rs2716610, and rs1050800. Rs10192566 was significantly associated with rosiglitazone treatment response. Patients with the G allele in rs10192566 had a larger decrease in fasting plasma glucose, 2-h postprandial glucose, and HbA1c than those without. This genetic effect remained significant after adjustment for age, sex, and initial body weight. No other SNPs were associated with response. These data suggest that LPIN1 genetic variations can affect rosiglitazone treatment response in T2DM.
Full Text
http://www.sciencedirect.com/science/article/pii/S1096719208001923
DOI
10.1016/j.ymgme.2008.06.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Park, Se Eun(박세은)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Seung Jin(한승진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106738
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