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LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients

DC Field Value Language
dc.contributor.author한승진-
dc.contributor.author강은석-
dc.contributor.author김경섭-
dc.contributor.author남정모-
dc.contributor.author박세은-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.date.accessioned2015-05-19T16:40:37Z-
dc.date.available2015-05-19T16:40:37Z-
dc.date.issued2008-
dc.identifier.issn1096-7192-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106738-
dc.description.abstractLipin1 protein, a product of the LPIN1 gene, is required for normal adipose tissue development and metabolism. Lipin1 deficiency results in immature adipocyte development in cases of mouse fatty liver dystrophy and human lipodystrophy. Recently, pioglitazone has been reported to increase human adipocyte lipin1 expression. We evaluated the effects of LPIN1 polymorphisms on rosiglitazone response in patients with type 2 diabetes (T2DM). A total of 262 patients were treated with 12 weeks of rosiglitazone (4 mg/day) in addition to their previous drug regimen medications. Six single nucleotide polymorphisms (SNPs) at the LPIN1 locus were genotyped: rs11693809, rs10192566, rs2278513, rs2577262, rs2716610, and rs1050800. Because rs11693809, rs10192566, and rs2278513 are in nearly complete linkage disequilibrium (D'>0.958, r(2) >0.882), we analyzed rs10192566, rs2577262, rs2716610, and rs1050800. Rs10192566 was significantly associated with rosiglitazone treatment response. Patients with the G allele in rs10192566 had a larger decrease in fasting plasma glucose, 2-h postprandial glucose, and HbA1c than those without. This genetic effect remained significant after adjustment for age, sex, and initial body weight. No other SNPs were associated with response. These data suggest that LPIN1 genetic variations can affect rosiglitazone treatment response in T2DM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent96~100-
dc.relation.isPartOfMOLECULAR GENETICS AND METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlood Glucose/analysis-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Mellitus, Type 2/drug therapy*-
dc.subject.MESHDiabetes Mellitus, Type 2/genetics*-
dc.subject.MESHDiabetes Mellitus, Type 2/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Variation*-
dc.subject.MESHGlycated Hemoglobin A/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents/administration & dosage*-
dc.subject.MESHLinkage Disequilibrium-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNuclear Proteins/genetics*-
dc.subject.MESHNuclear Proteins/metabolism-
dc.subject.MESHPhosphatidate Phosphatase-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHThiazolidinediones/administration & dosage*-
dc.titleLPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorSe Eun Park-
dc.contributor.googleauthorSeung Jin Han-
dc.contributor.googleauthorSo Hun Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorKyung Sub Kim-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.1016/j.ymgme.2008.06.011-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01264-
dc.contributor.localIdA04302-
dc.contributor.localIdA00068-
dc.contributor.localIdA00297-
dc.contributor.localIdA01521-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ02258-
dc.identifier.eissn1096-7206-
dc.identifier.pmid18693052-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1096719208001923-
dc.subject.keywordGenetic association-
dc.subject.keywordLipin-
dc.subject.keywordSNP-
dc.subject.keywordRosiglitazone-
dc.subject.keywordType 2 diabetes-
dc.subject.keywordPharmacogenetics-
dc.contributor.alternativeNameHan, Seung Jin-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Kyung Sup-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNamePark, Se Eun-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorHan, Seung Jin-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Kyung Sup-
dc.contributor.affiliatedAuthorPark, Se Eun-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.rights.accessRightsnot free-
dc.citation.volume95-
dc.citation.number1-2-
dc.citation.startPage96-
dc.citation.endPage100-
dc.identifier.bibliographicCitationMOLECULAR GENETICS AND METABOLISM, Vol.95(1-2) : 96-100, 2008-
dc.identifier.rimsid49335-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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