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Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture.

Authors
 Eun Jin Kim  ;  Ran Won  ;  Jin-Hun Sohn  ;  Myung-Ae Chung  ;  Taick Sang Nam  ;  Hye-Jung Lee  ;  Bae Hwan Lee 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.366(1) : 8-14, 2008 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2008
MeSH
Animals ; Antioxidants/administration & dosage ; Apoptosis/drug effects ; Ascorbic Acid/administration & dosage* ; Dehydroascorbic Acid/administration & dosage ; Dose-Response Relationship, Drug ; Hippocampus/cytology* ; Hippocampus/drug effects ; Hippocampus/metabolism* ; In Vitro Techniques ; Neurons/cytology* ; Neurons/drug effects ; Neurons/metabolism* ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism*
Keywords
Anti-oxidants ; Ascorbic acid ; Dehydroascorbic acid ; Kainic acid ; Reactive oxygen species ; Organotypic hippocampal slice culture
Abstract
Ascorbic acid (AA) and dehydroascorbic acid (DHA) have been shown to have protective effects as anti-oxidants in experimental neurological disorder models such as stroke, ischemia, and epileptic seizures. The present study was conducted to examine the protective effects of AA and DHA on kainic acid (KA) neurotoxicity using organotypic hippocampal slice cultures. After 12h KA treatment, significant delayed neuronal death was detected in the CA3, but not the CA1, region. Pretreatment with intermediate doses of AA and DHA significantly prevented cell death and inhibited reactive oxygen species (ROS) level, and mitochondrial dysfunction in the CA3 region. In contrast, pretreatment with low or high doses of AA or DHA was not effective. These data suggest that pretreatment with both AA and DHA has dose-dependent neuroprotective effects on KA-induced neuronal injury through inhibiting ROS generation and mitochondrial dysfunction.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X07024242
DOI
10.1016/j.bbrc.2007.11.050
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Won, Ran(원란)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106700
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