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Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

Authors
 B.-W. Park  ;  J.-W. Oh  ;  J.-H. Kim  ;  S. H. Park  ;  K.-S. Kim  ;  J. H. Kim  ;  K. S. Lee 
Citation
 ANNALS OF ONCOLOGY, Vol.19(4) : 675-681, 2008 
Journal Title
 ANNALS OF ONCOLOGY 
ISSN
 0923-7534 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biomarkers, Tumor/blood* ; Breast Neoplasms/blood* ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology* ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Carcinoembryonic Antigen/blood* ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Mucin-1/blood* ; Neoplasm Invasiveness ; Neoplasm Staging ; Predictive Value of Tests ; Preoperative Care ; Prognosis ; Proportional Hazards Models ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
Keywords
breast cancer ; CA 15-3 ; CEA ; prognosis ; tumor marker
Abstract
BACKGROUND: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. MATERIALS AND METHODS: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. RESULTS: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (> or =4), and advanced stage (> or =III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. CONCLUSION: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes
Files in This Item:
T200800514.pdf Download
DOI
10.1093/annonc/mdm538
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hee(김주희)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Oh, Jae Won(오재원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106698
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