286 488

Cited 132 times in

Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

DC Field Value Language
dc.contributor.author김주희-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author오재원-
dc.date.accessioned2015-05-19T16:39:16Z-
dc.date.available2015-05-19T16:39:16Z-
dc.date.issued2008-
dc.identifier.issn0923-7534-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106698-
dc.description.abstractBACKGROUND: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. MATERIALS AND METHODS: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. RESULTS: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (> or =4), and advanced stage (> or =III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. CONCLUSION: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes-
dc.description.statementOfResponsibilityopen-
dc.format.extent675~681-
dc.relation.isPartOfANNALS OF ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHBreast Neoplasms/blood*-
dc.subject.MESHBreast Neoplasms/drug therapy-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHBreast Neoplasms/radiotherapy-
dc.subject.MESHBreast Neoplasms/surgery-
dc.subject.MESHCarcinoembryonic Antigen/blood*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMucin-1/blood*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPreoperative Care-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titlePreoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorB.-W. Park-
dc.contributor.googleauthorJ.-W. Oh-
dc.contributor.googleauthorJ.-H. Kim-
dc.contributor.googleauthorS. H. Park-
dc.contributor.googleauthorK.-S. Kim-
dc.contributor.googleauthorJ. H. Kim-
dc.contributor.googleauthorK. S. Lee-
dc.identifier.doi10.1093/annonc/mdm538-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00952-
dc.contributor.localIdA02396-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.relation.journalcodeJ00171-
dc.identifier.eissn1569-8041-
dc.identifier.pmid18037623-
dc.subject.keywordbreast cancer-
dc.subject.keywordCA 15-3-
dc.subject.keywordCEA-
dc.subject.keywordprognosis-
dc.subject.keywordtumor marker-
dc.contributor.alternativeNameKim, Joo Hee-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.affiliatedAuthorKim, Joo Hee-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number4-
dc.citation.startPage675-
dc.citation.endPage681-
dc.identifier.bibliographicCitationANNALS OF ONCOLOGY, Vol.19(4) : 675-681, 2008-
dc.identifier.rimsid49310-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.