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Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration

Authors
 Chul Hyoung Lyoo  ;  Holger Prokisch  ;  Thomas Meitinger  ;  Seung Yeob Lee  ;  Do Hyoun Kim  ;  Myung Sik Lee 
Citation
 MOVEMENT DISORDERS, Vol.23(2) : 283-284, 2008 
Journal Title
 MOVEMENT DISORDERS 
ISSN
 0885-3185 
Issue Date
2008
MeSH
Adult ; Cholinergic Antagonists/therapeutic use* ; Gait Disorders, Neurologic/drug therapy* ; Gait Disorders, Neurologic/etiology ; Humans ; Magnetic Resonance Imaging ; Male ; Pantothenate Kinase-Associated Neurodegeneration/complications ; Pantothenate Kinase-Associated Neurodegeneration/drug therapy*
Keywords
gait freezing ; pantothenate kinase-associatedneurodegeneration ; anticholinergic
Abstract
A 43-year-old male patient suddenly developed freezing of gait (FOG) when making a first step, turning, or passing through a narrow path. Dystonic plantar flexion of his left foot always accompanied with FOG. He could walk without FOG when stepping on visual cues. Brain magnetic resonance imaging study showed typical "eye of the tiger" sign in the globus pallidus. He had heterozygous mutations in the exons 3 and 4 in the PANK2 gene. His FOG dramatically responded to the anticholinergic treatment. We report the first instance of a patient with genetically confirmed pantothenate kinase associated neurodegeneration showing typical FOG that responded to anticholinergic treatment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.21799/abstract
DOI
10.1002/mds.21799
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106643
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