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Simple microwire and microcatheter mechanical thrombolysis with adjuvant intraarterial urokinase for treatment of hyperacute ischemic stroke patients
DC Field | Value | Language |
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dc.contributor.author | 김동익 | - |
dc.contributor.author | 김동준 | - |
dc.contributor.author | 김응엽 | - |
dc.contributor.author | 변준수 | - |
dc.contributor.author | 서상현 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 정진영 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2015-05-19T16:36:44Z | - |
dc.date.available | 2015-05-19T16:36:44Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106623 | - |
dc.description.abstract | BACKGROUND: Mechanical thrombolysis may effectively enhance the efficacy of thrombolysis for hyperacute ischemic stroke patients. PURPOSE: To assess the feasibility and results of simple mechanical-based thrombolysis using microwire and microcatheter with adjuvant low-dose intraarterial (i.a.) urokinase (UK) for the treatment of hyperacute ischemic stroke. MATERIAL AND METHODS: Nineteen consecutive patients with hyperacute proximal middle cerebral artery (MCA) occlusions treated by a standardized protocol using microwire and microcatheter for mechanical thrombus disruption with adjuvant i.a. UK were reviewed. Simple to-and-fro passages through the clot with the microwire and microcatheter followed by disruptions by a J- or pigtail-shaped wire tip with alternating small-dose injections of UK distal, within, and proximal to the clot were performed. The recanalization rates, post-thrombolysis hemorrhage, and clinical outcome (baseline and discharge National Institute of Health Stroke Scale [NIHSS], mortality, 3-month modified Rankin scale [mRS]) were evaluated. RESULTS: Recanalization was achieved in 18 of 19 patients (94.7%). The mean UK dose was 375,789 IU (range 130,000-580,000 IU). Two patients (10.5%) developed symptomatic hemorrhage. One of the hemorrhages included a patient who developed subarachnoid hemorrhage. Mortality rate was 15.8% (n = 3). The median baseline NIHSS scores showed improvement from 17 to 10 at presentation and discharge, respectively. At three months, good outcome was noted in 11 of 19 patients (57.9%, mRS 0-2). CONCLUSION: Simple mechanical-based thrombolysis using microwire and microcatheter with adjuvant low-dose i.a. UK is safe and effective in achieving recanalization with good long-term outcome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 351~357 | - |
dc.relation.isPartOf | ACTA RADIOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Catheterization/instrumentation* | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Combined Modality Therapy/adverse effects | - |
dc.subject.MESH | Combined Modality Therapy/instrumentation | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrinolytic Agents/administration & dosage | - |
dc.subject.MESH | Fibrinolytic Agents/adverse effects | - |
dc.subject.MESH | Fibrinolytic Agents/therapeutic use* | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infarction, Middle Cerebral Artery/drug therapy* | - |
dc.subject.MESH | Injections, Intra-Arterial | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Thrombolytic Therapy/adverse effects | - |
dc.subject.MESH | Thrombolytic Therapy/instrumentation* | - |
dc.subject.MESH | Thrombolytic Therapy/methods | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Urokinase-Type Plasminogen Activator/administration & dosage | - |
dc.subject.MESH | Urokinase-Type Plasminogen Activator/adverse effects | - |
dc.subject.MESH | Urokinase-Type Plasminogen Activator/therapeutic use* | - |
dc.title | Simple microwire and microcatheter mechanical thrombolysis with adjuvant intraarterial urokinase for treatment of hyperacute ischemic stroke patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Kim DJ | - |
dc.contributor.googleauthor | Kim DI | - |
dc.contributor.googleauthor | Byun JS | - |
dc.contributor.googleauthor | Jung JY | - |
dc.contributor.googleauthor | Suh SH | - |
dc.contributor.googleauthor | Kim EY | - |
dc.contributor.googleauthor | Lee KY | - |
dc.contributor.googleauthor | Heo JH | - |
dc.identifier.doi | 10.1080/02841850701819143 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A00832 | - |
dc.contributor.localId | A01858 | - |
dc.contributor.localId | A01886 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J00033 | - |
dc.identifier.eissn | 1600-0455 | - |
dc.identifier.pmid | 18365826 | - |
dc.identifier.url | http://acr.sagepub.com/content/49/3/351.abstract | - |
dc.subject.keyword | CNS, interventional | - |
dc.subject.keyword | ischemia/infarction | - |
dc.subject.keyword | thrombolysis | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.alternativeName | Kim, Eung Yeop | - |
dc.contributor.alternativeName | Byun, Joon Soo | - |
dc.contributor.alternativeName | Suh, Sang Hyun | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Jung, Jin Young | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.contributor.affiliatedAuthor | Byun, Joon Soo | - |
dc.contributor.affiliatedAuthor | Suh, Sang Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 357 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, Vol.49(3) : 351-357, 2008 | - |
dc.identifier.rimsid | 46153 | - |
dc.type.rims | ART | - |
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