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Ketamine modulates calcium homeostasis in hypoxia-reoxygenated cardiomyocytes

Authors
 Jang Ho Roh  ;  Woo Chul Chang  ;  So Yeon Lim  ;  Hee Sang Song  ;  Byeong Wook Song  ;  Hye Jung Kim  ;  Min Ji Cha  ;  Yang Soo Jang  ;  Nam Sik Chung  ;  Yong Woo Hong  ;  Ki Chul Hwang 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(3) : 512-520, 2008 
Journal Title
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1738-2696 
Issue Date
2008
Keywords
calcium homeostasis ; cardiomyocytes ; hypoxia-reoxygenation ; ketamine
Abstract
Ketamine is clinically used as an inducer of anesthesia in critically ill patients because it has more stable hemodynamics than barbiturates or inhaled anesthetic agent. It has been known the effect of anesthetic related with calcium homeostasis in myocardium but there are few studies for myocardial protection of ketamine from ischemiareperfusion injury. We therefore observed protective effects of ketamine on survival of ischemia-reoxygenated cardiomyocytes in phosphorylation levels of Erk and Akt as well as suppression of pro-apoptotic protens, Bax and cytochrome C, and induction of anti-apoptotic protein, Bcl-2. Ketamine also overcame intracellular Ca2+ overload. We observed significant induction in transcript level of calreticulin, PMCA1, ion channels(L-type Ca2+-channel, Kir3.4, Kir6.1) and suppression in transcript level of calmodulin, and SERCA 2a in ketamine-treated cardiomyocytes. In conclusion, ketamine was protective of cardiomyocytesunder hypoxia-reperfusion condition. Therefore, we have provided new insight into myocardial protection of anesthetic agents so a better understanding of the role of anesthetics in the prevention of myocardial injury may provide strategies to improve outcome.
Full Text
http://search.koreanstudies.net/journal/thesis_name.asp?tname=kiss2002&key=3118912
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Roh, Jang Ho(노장호)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106600
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