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Ketamine modulates calcium homeostasis in hypoxia-reoxygenated cardiomyocytes

DC Field Value Language
dc.contributor.author노장호-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author황기철-
dc.date.accessioned2015-05-19T16:35:58Z-
dc.date.available2015-05-19T16:35:58Z-
dc.date.issued2008-
dc.identifier.issn1738-2696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106600-
dc.description.abstractKetamine is clinically used as an inducer of anesthesia in critically ill patients because it has more stable hemodynamics than barbiturates or inhaled anesthetic agent. It has been known the effect of anesthetic related with calcium homeostasis in myocardium but there are few studies for myocardial protection of ketamine from ischemiareperfusion injury. We therefore observed protective effects of ketamine on survival of ischemia-reoxygenated cardiomyocytes in phosphorylation levels of Erk and Akt as well as suppression of pro-apoptotic protens, Bax and cytochrome C, and induction of anti-apoptotic protein, Bcl-2. Ketamine also overcame intracellular Ca2+ overload. We observed significant induction in transcript level of calreticulin, PMCA1, ion channels(L-type Ca2+-channel, Kir3.4, Kir6.1) and suppression in transcript level of calmodulin, and SERCA 2a in ketamine-treated cardiomyocytes. In conclusion, ketamine was protective of cardiomyocytesunder hypoxia-reperfusion condition. Therefore, we have provided new insight into myocardial protection of anesthetic agents so a better understanding of the role of anesthetics in the prevention of myocardial injury may provide strategies to improve outcome.-
dc.description.statementOfResponsibilityopen-
dc.format.extent512~520-
dc.relation.isPartOfTISSUE ENGINEERING AND REGENERATIVE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleKetamine modulates calcium homeostasis in hypoxia-reoxygenated cardiomyocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJang Ho Roh-
dc.contributor.googleauthorWoo Chul Chang-
dc.contributor.googleauthorSo Yeon Lim-
dc.contributor.googleauthorHee Sang Song-
dc.contributor.googleauthorByeong Wook Song-
dc.contributor.googleauthorHye Jung Kim-
dc.contributor.googleauthorMin Ji Cha-
dc.contributor.googleauthorYang Soo Jang-
dc.contributor.googleauthorNam Sik Chung-
dc.contributor.googleauthorYong Woo Hong-
dc.contributor.googleauthorKi Chul Hwang-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01289-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ02734-
dc.identifier.eissn2212-5469-
dc.identifier.pmidcalcium homeostasis ; cardiomyocytes ; hypoxia-reoxygenation ; ketamine;-
dc.identifier.urlhttp://search.koreanstudies.net/journal/thesis_name.asp?tname=kiss2002&key=3118912-
dc.subject.keywordcalcium homeostasis-
dc.subject.keywordcardiomyocytes-
dc.subject.keywordhypoxia-reoxygenation-
dc.subject.keywordketamine-
dc.contributor.alternativeNameRoh, Jang Ho-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorRoh, Jang Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.rights.accessRightsnot free-
dc.citation.volume5-
dc.citation.number3-
dc.citation.startPage512-
dc.citation.endPage520-
dc.identifier.bibliographicCitationTISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(3) : 512-520, 2008-
dc.identifier.rimsid46135-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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