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Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions.

Authors
 Jae-Seon So  ;  Ho-Keun Kwon  ;  Choong-Gu Lee  ;  Hwa-Jung Yi  ;  Jin-A. Park  ;  So-Yeon Lim  ;  Ki-Chul Hwang  ;  Young Ho Jeon  ;  Sin-Hyeog Im 
Citation
 MOLECULAR IMMUNOLOGY, Vol.45(9) : 2690-2699, 2008 
Journal Title
MOLECULAR IMMUNOLOGY
ISSN
 0161-5890 
Issue Date
2008
MeSH
Administration, Oral ; Animals ; Arthritis,Experimental/immunology* ; Arthritis,Experimental/metabolism ; Arthritis, Rheumatoid/immunology* ; Arthritis, Rheumatoid/metabolism ; CD4-PositiveT-Lymphocytes/immunology ; CD4-PositiveT-Lymphocytes/metabolism ; Cartilage/cytology ; Cartilage/immunology ; Cartilage/metabolism ; Cell Proliferation ; Collagen Type II/immunology ; Cytokines/immunology ; Cytokines/metabolism* ; Down-Regulation ; Female ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism* ; Lactobacilluscasei/immunology* ; Lactobacilluscasei/metabolism ; Lymphocyte Activation ; Probiotics*/administration & dosage ; Rats ; Th1 Cells/immunology* ; Th1 Cells/metabolism
Keywords
Rheumatoid arthritis ; Collagen-induced arthritis ; Lactobacillus casei ; Probiotics ; CD4+T cells ; Cytokines
Abstract
Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating the effector functions of CD4(+) T cells. Oral administration of L. casei suppressed collagen-induced arthritis (CIA) and reduced paw swelling, lymphocyte infiltration and destruction of cartilage tissue. L. casei administration reduced type II collagen (CII)-reactive proinflammatory molecules (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha and Cox-2) by CD4(+) T cells. L. casei administration also reduced translocation of NF-kappaB into nucleus and CII-reactive Th1-type IgG isotypes IgG2a and IgG2b, while up-regulating immunoregulatory IL-10 levels. Our results suggest that oral administration of L. casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation
Full Text
http://www.sciencedirect.com/science/article/pii/S0161589007008942
DOI
10.1016/j.molimm.2007.12.010
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Lim, So Yeon(임소연)
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106594
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