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Enhanced calreticulin expression promotes calcium-dependent apoptosis in postnatal cardiomyocytes

DC FieldValueLanguage
dc.contributor.author김혜정-
dc.contributor.author송병욱-
dc.contributor.author이선주-
dc.contributor.author임소연-
dc.contributor.author장양수-
dc.contributor.author장우철-
dc.contributor.author정남식-
dc.contributor.author차민지-
dc.contributor.author황기철-
dc.date.accessioned2015-05-19T16:35:14Z-
dc.date.available2015-05-19T16:35:14Z-
dc.date.issued2008-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106578-
dc.description.abstractCalreticulin (CRT) is one of the major Ca2+ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this study, the molecular mechanisms that affect Ca2+-dependent signal cascades were investigated using CRT-overexpressing cardiomyocytes. In particular, we asked whether calreticulin plays a critical role in the activation of Ca2+-dependent apoptosis. In the cells overexpressing CRT, the intracellular calcium concentration was significantly increased and the activity of PKC and level of SECAR2a mRNA were reduced. Phosphorylation of Akt and ERKs decreased compared to control. In addition the activity of the anti-apoptotic factor, Bcl-2, was decreased and the activities of pro-apoptotic factor, Bax, p53 and caspase 8 were increased, leading to a dramatic augmentation of caspase 3 activity. Our results suggest that enhanced CRT expression in mature cardiomyocytes disrupts intracellular calcium regulation, leading to calcium-dependent apoptosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfMolecules and Cells-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEnhanced calreticulin expression promotes calcium-dependent apoptosis in postnatal cardiomyocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorSoyeon Lim-
dc.contributor.googleauthorWoochul Chang-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorHeesang Song-
dc.contributor.googleauthorJa Hyun Hong-
dc.contributor.googleauthorSunju Lee-
dc.contributor.googleauthorByeong-Wook Song-
dc.contributor.googleauthorHye-Jung Kim-
dc.contributor.googleauthorMin-Ji Cha-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorSoon-Yong Choi-
dc.contributor.googleauthorKi-Chul Hwang-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03373-1-
dc.contributor.localIdA03448-
dc.contributor.localIdA01178-
dc.contributor.localIdA02026-
dc.contributor.localIdA03452-
dc.contributor.localIdA03585-
dc.contributor.localIdA03995-
dc.contributor.localIdA04456-
dc.contributor.localIdA02859-
dc.relation.journalcodeJ02273-
dc.contributor.alternativeNameKim, Hye Jung-
dc.contributor.alternativeNameSong, Byeong Wook-
dc.contributor.alternativeNameLee, Sun Ju-
dc.contributor.alternativeNameLim, So Yeon-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Woo Chul-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCha, Min Ji-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorLim, So Yeon-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorKim, Hye Jung-
dc.contributor.affiliatedAuthorSong, Byeong Wook-
dc.contributor.affiliatedAuthorChang, Woo Chul-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCha, Min Ji-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.contributor.affiliatedAuthorLee, Sun Ju-
dc.rights.accessRightsfree-
dc.citation.volume25-
dc.citation.number3-
dc.citation.startPage390-
dc.citation.endPage396-
dc.identifier.bibliographicCitationMolecules and Cells, Vol.25(3) : 390-396, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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