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Association between serum resistin and carotid intima media thickness in hypertension patients

Authors
 Hyun-Joon Shin  ;  Sungha Park  ;  Se-Jung Yoon  ;  Dae Shik Choi  ;  Deok-Kyu Cho  ;  Jung-Sun Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.125(1) : 79-84, 2008 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2008
MeSH
Adipokines/blood ; Adult ; Aged ; Carotid Arteries/pathology* ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/pathology* ; Coronary Artery Disease/pathology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/blood ; Hypertension/pathology* ; Hypertension/physiopathology ; Inflammation ; Male ; Middle Aged ; Resistin/blood* ; Risk Factors ; Tunica Intima/pathology* ; Tunica Media/pathology*
Keywords
Resistin ; Carotid intima media thickness ; Hypertension
Abstract
BACKGROUND: Resistin is an adipocytokine belonging to the family of cysteine rich secretory proteins. We sought to determine if a correlation between resistin levels and carotid atherosclerosis exists in hypertensive patients. METHODS: This study consisted of 307 treated hypertensive patients. Subjects were grouped into tertiles according to their resistin level. RESULTS: Carotid intima media thickness (IMT) was significantly highest in the third tertile. The first tertile had a mean carotid IMT and a mean of maximum carotid IMT of 0.63+/-0.08 and 0.81+/-0.10 mm, respectively. The 2nd tertile had measurements of 0.63+/-0.08 and 0.81+/-0.12 mm, and the 3rd tertile 0.67+/-0.12 and 0.86+/-0.11 for the same parameters. (p=0.002). Resistin levels were independently associated with the carotid IMT (mean carotid IMT: R(2)=0.159, p<0.001 and mean of maximum carotid IMT: R(2)=0.162, p<0.001) after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking and DM. The tertile level of resistin was significantly associated with (odds ratio=3.097, p=0.004) risk of coronary artery disease after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking, DM and carotid IMT. CONCLUSION: Serum resistin is independently associated with increasing carotid IMT in treated hypertensive patients
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527307005189
DOI
10.1016/j.ijcard.2007.02.028
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shin, Hyun Joon(신현준)
Yoon, Se Jung(윤세정)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dae Sik(최대식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106563
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