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Allelic frequencies and heterozygosities of microsatellite markers covering the whole genome in the Korean

Authors
 M.-H. Park  ;  K.-S. Kim  ;  H.-J. Lee  ;  Y.-M. Cho  ;  H.-K. Lee  ;  K.-S. Park  ;  D.-J. Shin  ;  Y. Jang  ;  K.-J. Kim  ;  J. Jung  ;  H.-L. Kim  ;  B. Oh  ;  J.-Y. Lee 
Citation
 JOURNAL OF HUMAN GENETICS, Vol.53(3) : 254-266, 2008 
Journal Title
 JOURNAL OF HUMAN GENETICS 
ISSN
 1434-5161 
Issue Date
2008
MeSH
Asian Continental Ancestry Group/genetics* ; European Continental Ancestry Group/genetics ; Family ; Gene Frequency* ; Genetic Carrier Screening ; Genetic Markers ; Genome, Human* ; Humans ; Korea ; Microsatellite Repeats/genetics* ; Taiwan/ethnology
Keywords
Microsatellite marker ; Allele frequency ; Heterozygosity ; Linkage ; IBD ; Korean
Abstract
Microsatellite markers are an essential tool for genetic linkage analysis because of their high polymorphism content. Four hundred commercially available markers covering the entire genome were genotyped from 578 sib individuals from 249 Korean families. Allelic frequencies and heterozygosities were determined for each marker loci and compared between Korean, Taiwanese, Japanese and Caucasian populations. In the three Asian populations, 10-13% of the markers had less than 0.6 heterozygosity, whereas in the Caucasian population, only 0.5% of the markers had less than 0.6 heterozygosity. Mean identical by descent (IBD) values were calculated for 578 sib individuals. Analysis of IBD values greater than 0.5 suggested that markers with low heterozygosity can also provide positive linkages, at least for the IBD sharing method of model-free linkage analysis. The data presented in this study will be a useful reference for genome-wide screens of Koreans and comparative studies with other ethnic populations.
Full Text
http://www.nature.com/jhg/journal/v53/n3/full/jhg200831a.html
DOI
10.1007/s10038-008-0247-5
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106561
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