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A multi-institutional study on histopathological characteristics of surgically treated renal tumors: The importance of tumor size

 Sun Il Kim  ;  Yeung Deuk Choi  ;  Se Joong Kim  ;  Byung Ha Chung  ;  Do Hwan Seong  ;  Chun Il Kim  ;  Sang Hyeon Cheon  ;  Jin Seon Cho  ;  Yun Seob Song  ;  Young Sig Kim  ;  In Rae Cho  ;  Dong Hyeon Lee  ;  Ki Hak Song  ;  Hong Sup Kim  ;  Joong Shik Lee  ;  Won Jae Yang  ;  Sung Joon Hong 
 YONSEI MEDICAL JOURNAL, Vol.49(4) : 639-646, 2008 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Kidney Neoplasms/classification ; Kidney Neoplasms/pathology* ; Kidney Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Staging
Kidney neoplasms ; renal cell carcinoma ; nephrectomy ; surgical pathology
PURPOSE: The incidence of accidentally detected small renal tumors is increasing throughout the world. In this multi-institutional study performed in Korea, histopathological characteristics of contemporarily surgically removed renal tumors were reviewed with emphasis on tumor size. MATERIALS and METHODS: Between January 1995 and May 2005, 1,702 patients with a mean age of 55 years underwent surgical treatment at 14 training hospitals in Korea for radiologically suspected malignant renal tumors. Clinicopathological factors and patient survival were analyzed. RESULTS: Of the 1,702 tumors, 91.7% were malignant and 8.3% were benign. The percentage of benign tumors was significantly greater among those < or = 4cm (13.2%) than those > 4cm (4.5%) (p < 0.001). Among renal cell carcinoma patients, the percentage of tumors classed as stage > or = T3 was significantly less among tumors < or = 4cm (5.2%) than those > 4cm (26.8%) (p < 0.001). The percentage of tumors classed as Fuhrman's nuclear grades > or = 3 was also significantly less among tumors < or = 4cm (27.3%) than tumors > 4cm (50.9%) (p < 0.001). The 5-year cancer-specific survival rate was 82.7%, and T stage (p < 0.001), N stage (p < 0.001), M stage (p = 0.025), and Fuhrman's nuclear (p < 0.001) grade were the only independent predictors of cancer-specific survival. CONCLUSION: In renal tumors, small tumor size is prognostic for favorable postsurgical histopathologies such as benign tumors, low T stages, and low Fuhrman's nuclear grades. Our observations are expected to facilitate urologists to adopt function-preserving approach in the planning of surgery for small renal tumors with favorable predicted outcomes.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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