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흰쥐에서 신장 부분 절제후 Oxidized Regenerated Cellulose 및 돼지 Small Intestine Submucosa를 삽입 후 생체 적합성 비교

Other Titles
 Comparison of the Intraparenchymal Biocompatibility of Oxidized Regenerated Cellulose and Porcine Small Intestine Submucosa in Rat Kidney. 
Authors
 한웅규  ;  김세훈  ;  박종필  ;  양승철 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.49(1) : 43-48, 2008 
Journal Title
KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지)
ISSN
 0494-4747 
Issue Date
2008
Keywords
Biocompatibility ; Kidney ; Rats
Abstract
PURPOSE: The objective of this study was to evaluate the biological properties of a variety of materials that could be used in partial nephrectomy. MATERIALS AND METHODS: 54 Sprague-Dawley rats(9 for each group) divided into an experimental period of 4 and 12 weeks, respectively. 2 other groups were the negative control for this experiment. We inserted oxidized regenerated cellulose and porcine small intestine submucosa into the defected renal parenchyme in the experimental groups. At the end of the observation periods, the animals were killed and their specimens prepared for histological examination to evaluate the different materials biocompatibility. RESULTS: The reaction of the tissue to the materials diminished with time. After analyzing both periods, the inflammatory reactions to oxidized regenerated cellulose and porcine small intestine submucosa were considered slight. There were no significant differences between oxidized regenerated cellulose and porcine small intestine submucosa. Oxidized regenerated cellulose and porcine small intestine submucosa showed biocompatibility in this test model at both time periods. CONCLUSIONS: It was concluded that there was no difference of biocompatibility between oxidized regenerated cellulose and porcine small intestine submucosa. Both materials are safe, biocompatible materials that can be inserted into the renal parenchyma.
Files in This Item:
T200800331.pdf Download
DOI
10.4111/kju.2008.49.1.43
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Jong Pil(박종필) ORCID logo https://orcid.org/0000-0002-6525-3012
Yang, Seung Choul(양승철)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106487
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