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An extension of the Regression of Offspring on Mid-Parent to test for association and estimate locus-specific heritability: The revised ROMP method

Authors
 M.-H. Roy-Gagnon  ;  R. A. Mathias  ;  M. D. Fallin  ;  S. H. Jee  ;  K. W. Broman  ;  A. F. Wilson 
Citation
 ANNALS OF HUMAN GENETICS, Vol.72(pt 1) : 115-125, 2008 
Journal Title
ANNALS OF HUMAN GENETICS
ISSN
 0003-4800 
Issue Date
2008
MeSH
Cardiovascular Diseases/genetics* ; Computer Simulation ; Fibrinogen/genetics ; Humans ; Korea ; Multigene Family ; Nuclear Family* ; Parents* ; Polymorphism, Genetic ; Quantitative Trait Loci* ; Regression Analysis ; Research Design*
Keywords
association tests ; quantitative trait ; parent‐offspring trios ; candidate gene ; cardiovascular disease
Abstract
The Regression of Offspring on Mid-Parent (ROMP) method is a test of association between a quantitative trait and a candidate locus. ROMP estimates the trait heritability and the heritability attributable to a locus and requires genotyping the offspring only. In this study, the theory underlying ROMP was revised (ROMP(rev)) and extended. Computer simulations were used to determine the type I error and power of the test of association, and the accuracy of the locus-specific heritability estimate. The ROMP(rev) test had good power at the 5% significance level with properly controlled type I error. Locus-specific heritability estimates were, on average, close to simulated values. For non-zero locus-specific heritability, the proposed standard error was downwardly biased, yielding reduced coverage of 95% confidence intervals. A bootstrap approach with proper coverage is suggested as a second step for loci of interest. ROMP(rev) was applied to a study of cardiovascular-related traits to illustrate its use. An association between polymorphisms within the fibrinogen gene cluster and plasma fibrinogen was detected (p < 0.005) that accounted for 29% of the estimated fibrinogen heritability. The ROMP(rev) method provides a computationally fast and simple way of testing for association and obtaining accurate estimates of locus-specific heritability while minimizing the genotyping required
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2007.00401.x/abstract
DOI
10.1111/j.1469-1809.2007.00401.x
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106474
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