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An extension of the Regression of Offspring on Mid-Parent to test for association and estimate locus-specific heritability: The revised ROMP method

DC Field Value Language
dc.contributor.author지선하-
dc.date.accessioned2015-05-19T16:31:46Z-
dc.date.available2015-05-19T16:31:46Z-
dc.date.issued2008-
dc.identifier.issn0003-4800-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106474-
dc.description.abstractThe Regression of Offspring on Mid-Parent (ROMP) method is a test of association between a quantitative trait and a candidate locus. ROMP estimates the trait heritability and the heritability attributable to a locus and requires genotyping the offspring only. In this study, the theory underlying ROMP was revised (ROMP(rev)) and extended. Computer simulations were used to determine the type I error and power of the test of association, and the accuracy of the locus-specific heritability estimate. The ROMP(rev) test had good power at the 5% significance level with properly controlled type I error. Locus-specific heritability estimates were, on average, close to simulated values. For non-zero locus-specific heritability, the proposed standard error was downwardly biased, yielding reduced coverage of 95% confidence intervals. A bootstrap approach with proper coverage is suggested as a second step for loci of interest. ROMP(rev) was applied to a study of cardiovascular-related traits to illustrate its use. An association between polymorphisms within the fibrinogen gene cluster and plasma fibrinogen was detected (p < 0.005) that accounted for 29% of the estimated fibrinogen heritability. The ROMP(rev) method provides a computationally fast and simple way of testing for association and obtaining accurate estimates of locus-specific heritability while minimizing the genotyping required-
dc.description.statementOfResponsibilityopen-
dc.format.extent115~125-
dc.relation.isPartOfANNALS OF HUMAN GENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCardiovascular Diseases/genetics*-
dc.subject.MESHComputer Simulation-
dc.subject.MESHFibrinogen/genetics-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMultigene Family-
dc.subject.MESHNuclear Family*-
dc.subject.MESHParents*-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHQuantitative Trait Loci*-
dc.subject.MESHRegression Analysis-
dc.subject.MESHResearch Design*-
dc.titleAn extension of the Regression of Offspring on Mid-Parent to test for association and estimate locus-specific heritability: The revised ROMP method-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorM.-H. Roy-Gagnon-
dc.contributor.googleauthorR. A. Mathias-
dc.contributor.googleauthorM. D. Fallin-
dc.contributor.googleauthorS. H. Jee-
dc.contributor.googleauthorK. W. Broman-
dc.contributor.googleauthorA. F. Wilson-
dc.identifier.doi10.1111/j.1469-1809.2007.00401.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00163-
dc.identifier.eissn1469-1809-
dc.identifier.pmid18042270-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2007.00401.x/abstract-
dc.subject.keywordassociation tests-
dc.subject.keywordquantitative trait-
dc.subject.keywordparent‐offspring trios-
dc.subject.keywordcandidate gene-
dc.subject.keywordcardiovascular disease-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsnot free-
dc.citation.volume72-
dc.citation.numberpt 1-
dc.citation.startPage115-
dc.citation.endPage125-
dc.identifier.bibliographicCitationANNALS OF HUMAN GENETICS, Vol.72(pt 1) : 115-125, 2008-
dc.identifier.rimsid45944-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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