Cited 4 times in
An extension of the Regression of Offspring on Mid-Parent to test for association and estimate locus-specific heritability: The revised ROMP method
DC Field | Value | Language |
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dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-05-19T16:31:46Z | - |
dc.date.available | 2015-05-19T16:31:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0003-4800 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106474 | - |
dc.description.abstract | The Regression of Offspring on Mid-Parent (ROMP) method is a test of association between a quantitative trait and a candidate locus. ROMP estimates the trait heritability and the heritability attributable to a locus and requires genotyping the offspring only. In this study, the theory underlying ROMP was revised (ROMP(rev)) and extended. Computer simulations were used to determine the type I error and power of the test of association, and the accuracy of the locus-specific heritability estimate. The ROMP(rev) test had good power at the 5% significance level with properly controlled type I error. Locus-specific heritability estimates were, on average, close to simulated values. For non-zero locus-specific heritability, the proposed standard error was downwardly biased, yielding reduced coverage of 95% confidence intervals. A bootstrap approach with proper coverage is suggested as a second step for loci of interest. ROMP(rev) was applied to a study of cardiovascular-related traits to illustrate its use. An association between polymorphisms within the fibrinogen gene cluster and plasma fibrinogen was detected (p < 0.005) that accounted for 29% of the estimated fibrinogen heritability. The ROMP(rev) method provides a computationally fast and simple way of testing for association and obtaining accurate estimates of locus-specific heritability while minimizing the genotyping required | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 115~125 | - |
dc.relation.isPartOf | ANNALS OF HUMAN GENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cardiovascular Diseases/genetics* | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Fibrinogen/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Multigene Family | - |
dc.subject.MESH | Nuclear Family* | - |
dc.subject.MESH | Parents* | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Quantitative Trait Loci* | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Research Design* | - |
dc.title | An extension of the Regression of Offspring on Mid-Parent to test for association and estimate locus-specific heritability: The revised ROMP method | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | M.-H. Roy-Gagnon | - |
dc.contributor.googleauthor | R. A. Mathias | - |
dc.contributor.googleauthor | M. D. Fallin | - |
dc.contributor.googleauthor | S. H. Jee | - |
dc.contributor.googleauthor | K. W. Broman | - |
dc.contributor.googleauthor | A. F. Wilson | - |
dc.identifier.doi | 10.1111/j.1469-1809.2007.00401.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00163 | - |
dc.identifier.eissn | 1469-1809 | - |
dc.identifier.pmid | 18042270 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2007.00401.x/abstract | - |
dc.subject.keyword | association tests | - |
dc.subject.keyword | quantitative trait | - |
dc.subject.keyword | parent‐offspring trios | - |
dc.subject.keyword | candidate gene | - |
dc.subject.keyword | cardiovascular disease | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 72 | - |
dc.citation.number | pt 1 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 125 | - |
dc.identifier.bibliographicCitation | ANNALS OF HUMAN GENETICS, Vol.72(pt 1) : 115-125, 2008 | - |
dc.identifier.rimsid | 45944 | - |
dc.type.rims | ART | - |
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