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Body mass index and cancer risk in Korean men and women

Authors
 Sun Ha Jee  ;  Ji Eun Yun  ;  Eun Jung Park  ;  Eo Rin Cho  ;  Il Su Park  ;  Jae Woong Sull  ;  Heechoul Ohrr  ;  Jonathan M Samet 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.123(8) : 1892-1896, 2008 
Journal Title
INTERNATIONAL JOURNAL OF CANCER
ISSN
 0020-7136 
Issue Date
2008
MeSH
Age Factors ; Body Mass Index* ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged ; Neoplasms/epidemiology* ; Obesity/epidemiology ; Prospective Studies ; Risk Factors ; Smoking
Keywords
body mass index ; incidence ; cancer ; smoking ; gender
Abstract
Obesity is associated with diverse health risks, but the role of body weight (BMI) as a risk factor for all and site-specific cancers remains controversial and risks for cancer associated with obesity have not been well-characterized in Asians. Body weight and risk for cancer were examined in a 14-year prospective cohort study of 1,213,829 Koreans aged 30-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation in 1992-1995. Incidence rates for all cancers and site-specific cancers were examined in relation to BMI. Age- and smoking-status adjusted hazard ratios (HR) with 95% confidence intervals (CI) were examined using the Cox proportional hazards model. For both sexes, the average baseline BMI was 23.2 kg/m(2), and the association of risk for all-cancers with BMI was positive. Obese men (BMI >or= 30 kg/m(2)) were at increased risk for developing the following cancers: stomach (1.31, 1.05-1.64), colon (1.42, 1.02-1.98), liver (1.63, 1.27-2.10) and gallbladder (1.65, 1.11-2.44). Obese women (BMI >or= 30 kg/m(2)) were at increased risk for developing liver cancer (1.39, 1.00-1.94), pancreatic cancer (1.80, 1.14-2.86) and breast cancer among women aged >or=50 years old (1.38, 1.00-1.90). The HRs were comparable in never and ever smokers for all cancers and all specific sites except for lung cancer. For all cancers common to both sexes, the association was significantly weaker (p < 0.01) in females. Our study provides further confirmation of the excess cancer risk associated with obesity. Rising obesity in Asian populations raises concern that increasing numbers of avoidable cancer cases will occur among Asians.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ijc.23719/abstract
DOI
10.1002/ijc.23719
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Ohrr, Hee Choul(오희철)
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106470
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