0 512

Cited 5 times in

Genetic characterization and assessment of authenticity of ancient Korean skeletal remains

Authors
 Hwan Young Lee  ;  Ji-Eun Yoo  ;  Myung Jin Park  ;  Chong-Youl Kim  ;  Kyoung-Jin Shin 
Citation
 HUMAN BIOLOGY, Vol.80(3) : 239-250, 2008 
Journal Title
HUMAN BIOLOGY
ISSN
 0018-7143 
Issue Date
2008
MeSH
Base Sequence ; Bone and Bones* ; DNA, Mitochondrial/genetics* ; Databases, Genetic ; Genetics, Population/statistics & numerical data* ; Haplotypes ; Humans ; Korea ; Nucleic Acid Amplification Techniques ; Pilot Projects ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Skeleton* ; Tooth*
Keywords
MITOCHONDRIAL DNA ; ANCIENT KOREANS ; HAPLOGROUP ; AUTHENTICITY ; EAST ASIAN MIGRATION ROUTES
Abstract
To study the maternal lineage history of Korea, we extracted DNA from the skeletal remains of 35 museum samples (some dating back to the Paleolithic Age) excavated from 11 local burial sites scattered throughout southern Korea. Mitochondrial DNA (mtDNA) control region sequences (HV1, HV2, and HV3) were successfully determined for 11 samples with no sharing of the control region polymorphisms with individuals involved in the laboratory analyses. Each of the 11 mtDNAs was assigned to the appropriate East Asian mtDNA haplogroup according to the haplogroup-specific control region mutation motif and diagnostic coding region single nucleotide polymorphism. The successful mtDNA haplogroup determination for each ancient Korean mtDNA and the confirmation of the absence of abnormal mutations based on the haplogroup-directed database comparisons indicates that there is no mosaic structure from cross-contamination or sample mix-up or other errors in our mtDNA sequences. The presence of haplogroups B, D, and G in the prehistoric age is consistent with the hypothesis that the early Korean population has a common origin in the northern regions of the Altai Mountains and Lake Baikal of southeastern Siberia. In addition, the modern Korean population, which possesses lineages from both southern and northern haplogroups, suggests additional gene flow from southern Asian haplogroups in recent times, but many more ancient samples need to be analyzed to directly tell whether there was regional continuity or replacement of early lineages by other lineages in ancient Korea.
Full Text
http://www.bioone.org/doi/abs/10.3378/1534-6617-80.3.239
DOI
10.3378/1534-6617-80.3.239
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열)
Park, Myung Jin(박명진)
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Yoo, Ji Eun(유지은)
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106450
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links