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Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma.

Authors
 Sung-Weon Choi  ;  Joo-Young Kim  ;  Joo-Yong Park  ;  In-Ho Cha  ;  Jin Kim  ;  Sun Lee 
Citation
 HUMAN PATHOLOGY, Vol.39(9) : 1317-1322, 2008 
Journal Title
 HUMAN PATHOLOGY 
ISSN
 0046-8177 
Issue Date
2008
MeSH
Antigens, Neoplasm/biosynthesis* ; Carbonic Anhydrase IX ; Carbonic Anhydrases/biosynthesis* ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology* ; Carcinoma, Squamous Cell/surgery ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology* ; Mouth Neoplasms/surgery ; Neoplasm Recurrence, Local/diagnosis ; Prognosis
Keywords
CA9 protein ; Mouth neoplasms ; Prognosis
Abstract
Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity squamous cell carcinoma (SCC). Immunohistochemical staining with anti-CA9 antibody was performed in 117 oral SCC samples. Clinicopathologic factors were correlated with the results of CA9 expression. CA9 expression was restricted to tumor cells and did not appear in the corresponding normal tissue. Among 117 samples, 68 (58.1%) tumors displayed CA9 overexpression. CA9 expression was significantly associated with postoperative recurrence (P = .05) and poor overall survival (P = .02). CA9 expression was also associated with male sex, lymph node metastasis, and smoking history, but these correlations did not reach statistical significance. In conclusion, CA9 expression was a frequent and tumor-specific event in oral SCC. CA9 demonstrated significant associations with disease recurrence and poor clinical outcome and shows potential as a prognostic factor for oral SCC
Full Text
http://www.sciencedirect.com/science/article/pii/S0046817707005795
DOI
10.1016/j.humpath.2007.10.026
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106444
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