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Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma.

DC Field Value Language
dc.contributor.author김진-
dc.contributor.author차인호-
dc.date.accessioned2015-05-19T16:30:47Z-
dc.date.available2015-05-19T16:30:47Z-
dc.date.issued2008-
dc.identifier.issn0046-8177-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106444-
dc.description.abstractCarbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity squamous cell carcinoma (SCC). Immunohistochemical staining with anti-CA9 antibody was performed in 117 oral SCC samples. Clinicopathologic factors were correlated with the results of CA9 expression. CA9 expression was restricted to tumor cells and did not appear in the corresponding normal tissue. Among 117 samples, 68 (58.1%) tumors displayed CA9 overexpression. CA9 expression was significantly associated with postoperative recurrence (P = .05) and poor overall survival (P = .02). CA9 expression was also associated with male sex, lymph node metastasis, and smoking history, but these correlations did not reach statistical significance. In conclusion, CA9 expression was a frequent and tumor-specific event in oral SCC. CA9 demonstrated significant associations with disease recurrence and poor clinical outcome and shows potential as a prognostic factor for oral SCC-
dc.description.statementOfResponsibilityopen-
dc.format.extent1317~1322-
dc.relation.isPartOfHUMAN PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntigens, Neoplasm/biosynthesis*-
dc.subject.MESHCarbonic Anhydrase IX-
dc.subject.MESHCarbonic Anhydrases/biosynthesis*-
dc.subject.MESHCarcinoma, Squamous Cell/diagnosis-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCarcinoma, Squamous Cell/surgery-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMouth Neoplasms/diagnosis-
dc.subject.MESHMouth Neoplasms/pathology*-
dc.subject.MESHMouth Neoplasms/surgery-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis-
dc.subject.MESHPrognosis-
dc.titleExpression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorSung-Weon Choi-
dc.contributor.googleauthorJoo-Young Kim-
dc.contributor.googleauthorJoo-Yong Park-
dc.contributor.googleauthorIn-Ho Cha-
dc.contributor.googleauthorJin Kim-
dc.contributor.googleauthorSun Lee-
dc.identifier.doi10.1016/j.humpath.2007.10.026-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04002-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ01011-
dc.identifier.eissn1532-8392-
dc.identifier.pmid18440050-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0046817707005795-
dc.subject.keywordCA9 protein-
dc.subject.keywordMouth neoplasms-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.contributor.affiliatedAuthorKim, Jin-
dc.rights.accessRightsnot free-
dc.citation.volume39-
dc.citation.number9-
dc.citation.startPage1317-
dc.citation.endPage1322-
dc.identifier.bibliographicCitationHUMAN PATHOLOGY, Vol.39(9) : 1317-1322, 2008-
dc.identifier.rimsid45925-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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