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RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma

Authors
 Myung Hyun Sohn  ;  Seung-Hyun Kim  ;  Kyung-Won Kim  ;  Hye Mi Jee  ;  Hae-Sim Park  ;  Kyu-Earn Kim 
Citation
 LUNG, Vol.186(1) : 37-43, 2008 
Journal Title
 LUNG 
ISSN
 0341-2040 
Issue Date
2008
MeSH
Adolescent ; Asthma/diagnosis ; Asthma/genetics* ; Asthma/physiopathology ; Bronchial Hyperreactivity/diagnosis ; Bronchial Hyperreactivity/genetics* ; Bronchial Hyperreactivity/physiopathology ; Bronchial Provocation Tests ; Bronchoconstrictor Agents ; Case-Control Studies ; Chemokine CCL5/genetics* ; Child ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Homozygote ; Humans ; Korea ; Male ; Methacholine Chloride ; Phenotype ; Polymorphism, Genetic* ; Promoter Regions, Genetic* ; Risk Factors
Keywords
Asthma ; Bronchial hyperresponsiveness ; Polymorphism ; RANTES
Abstract
Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease. The aim of this study was to evaluate the possible role of RANTES promoter polymorphisms in children with asthma. We genotyped 271 children with atopic asthma, 55 children with nonatopic asthma, and 253 control children for allelic determinants at two polymorphic sites in the promoter region at positions -403G>A and -28C>G by restriction fragment length polymorphism methods. There was no significant difference in genotype and allele frequencies of the RANTES -403G>A and -28C>G polymorphisms when the atopic asthma, nonatopic asthma, and control groups were compared. However, atopic asthmatic patients who were homozygous GG for the RANTES -28C>G tended to have lower PC20 methacholine than those carrying the wild genotype. In addition, a significantly lower PC20 was demonstrated for the homozygous haplotype -403A/-28G in asthmatic children. The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
Full Text
http://link.springer.com/article/10.1007%2Fs00408-007-9049-3
DOI
10.1007/s00408-007-9049-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Jee, Hye Mi(지혜미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106357
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