Cited 14 times in
RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 지혜미 | - |
dc.date.accessioned | 2015-05-19T16:27:58Z | - |
dc.date.available | 2015-05-19T16:27:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106357 | - |
dc.description.abstract | Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease. The aim of this study was to evaluate the possible role of RANTES promoter polymorphisms in children with asthma. We genotyped 271 children with atopic asthma, 55 children with nonatopic asthma, and 253 control children for allelic determinants at two polymorphic sites in the promoter region at positions -403G>A and -28C>G by restriction fragment length polymorphism methods. There was no significant difference in genotype and allele frequencies of the RANTES -403G>A and -28C>G polymorphisms when the atopic asthma, nonatopic asthma, and control groups were compared. However, atopic asthmatic patients who were homozygous GG for the RANTES -28C>G tended to have lower PC20 methacholine than those carrying the wild genotype. In addition, a significantly lower PC20 was demonstrated for the homozygous haplotype -403A/-28G in asthmatic children. The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 37~43 | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Asthma/diagnosis | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Asthma/physiopathology | - |
dc.subject.MESH | Bronchial Hyperreactivity/diagnosis | - |
dc.subject.MESH | Bronchial Hyperreactivity/genetics* | - |
dc.subject.MESH | Bronchial Hyperreactivity/physiopathology | - |
dc.subject.MESH | Bronchial Provocation Tests | - |
dc.subject.MESH | Bronchoconstrictor Agents | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chemokine CCL5/genetics* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Homozygote | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methacholine Chloride | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Seung-Hyun Kim | - |
dc.contributor.googleauthor | Kyung-Won Kim | - |
dc.contributor.googleauthor | Hye Mi Jee | - |
dc.contributor.googleauthor | Hae-Sim Park | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.identifier.doi | 10.1007/s00408-007-9049-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A03973 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 17990036 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00408-007-9049-3 | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | Bronchial hyperresponsiveness | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | RANTES | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Jee, Hye Mi | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Jee, Hye Mi | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 186 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 43 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.186(1) : 37-43, 2008 | - |
dc.identifier.rimsid | 44373 | - |
dc.type.rims | ART | - |
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