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Novel biomarker candidates for gastric cancer

Authors
 SANGHWA YANG  ;  HYUN CHEOL CHUNG 
Citation
 ONCOLOGY REPORTS, Vol.19(3) : 675-680, 2008 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
2008
MeSH
Algorithms ; Biomarkers, Tumor/classification ; Biomarkers, Tumor/genetics* ; Biomarkers, Tumor/metabolism ; Chromogranin A/genetics ; Chromogranin A/metabolism ; Gene Expression Profiling ; Humans ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/metabolism ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism
Keywords
Algorithms ; Biomarkers, Tumor/classification ; Biomarkers, Tumor/genetics* ; Biomarkers, Tumor/metabolism ; Chromogranin A/genetics ; Chromogranin A/metabolism ; Gene Expression Profiling ; Humans ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/metabolism ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism
Abstract
Gastric cancer continues to be a major threat to human health. Molecular descriptions on the diverse phases of this disease will be valuable for a better diagnosis and development of therapeutic targets. Previously, a 92-gene classifier that distinguishes tumor from non-tumor gastric tissues was proposed. To corroborate this finding, independent approaches of gene selection and class prediction algorithm were applied to the dataset of 86 tissues profiled on 17K cDNA microarrays. As a result, 22 genes were selected, of which 18 were in common with 92 genes previously shown. The differential expression patterns of Chromogranin A (CHGA) and Thy-1 cell surface antigen (THY1) were further validated with immunohistostaining on gastric tissue microarrays. The differential expression patterns of several of the proposed genes have been proven to be critical for tumor progression in other cancer models and will likely function as novel biomarkers for gastric cancer as well.
Full Text
http://www.spandidos-publications.com/or/19/3/675
DOI
18288401
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
Yonsei Authors
Yang, Sang Hwa(양상화)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106347
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