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Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome

 Su Jeong You  ;  Hoon-Chul Kang  ;  Tae-Sung Ko  ;  Heung Dong Kim  ;  Mi-Sun Yum  ;  Yong Soon Hwang  ;  Jung-Kyo Lee  ;  Dong Suk Kim  ;  Sang Keun Park 
 BRAIN & DEVELOPMENT, Vol.30(3) : 195-199, 2008 
Journal Title
Issue Date
Child ; Child, Preschool ; Combined Modality Therapy ; Corpus Callosum/surgery* ; Electric Stimulation Therapy/methods* ; Epilepsy/pathology ; Epilepsy/therapy* ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Male ; Psychosurgery/methods* ; Time Factors ; Treatment Outcome ; Vagus Nerve/physiopathology* ; Vagus Nerve/radiation effects
Corpus callosotomy ; Vagus nerve stimulation ; Lennox–Gastaut syndrome
PURPOSE: To compare the efficacy of corpus callosotomy and vagus nerve stimulation (VNS) for long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: Fourteen patients underwent a total corpus callosotomy and 10 patients received VNS implantation. The patients were monitored for more than 12 months after treatment, and seizure rates and complications were retrospectively evaluated. RESULTS: Seizure types among the 24 patients included atonic or tonic seizures with head-drops in 17 patients, generalized tonic seizures in two patients, atypical absence seizures in one patient, generalized tonic-clonic seizures in one patient, and myoclonic seizures in three patients. Of the 14 patients who underwent a corpus callosotomy, nine (64.3%) had a greater than 50% reduction in seizure frequency and five (35.7%) had a greater than 75% reduction. Of the 10 patients who underwent VNS implantation, seven (70.0%) had a greater than 50% reduction in seizure frequency and two (20.0%) had a greater than 75% reduction. There was no significant difference between the two procedures in terms of final efficacy. Complications of corpus callosotomy included aphasia in one patient, ataxia in another, and paresis in a third. Among patients receiving VNS, one patient experienced dyspnea while sleeping and one patient suffered from drooling. These complications were transient and tolerable, and were controlled by simple adjustments of VNS treatment parameters. CONCLUSION: The efficacy and safety of corpus callosotomy and VNS were comparable in children with LGS.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
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