2 647

Cited 83 times in

Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome

DC Field Value Language
dc.contributor.author김흥동-
dc.contributor.author김동석-
dc.date.accessioned2015-05-19T16:26:53Z-
dc.date.available2015-05-19T16:26:53Z-
dc.date.issued2008-
dc.identifier.issn0387-7604-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106323-
dc.description.abstractPURPOSE: To compare the efficacy of corpus callosotomy and vagus nerve stimulation (VNS) for long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: Fourteen patients underwent a total corpus callosotomy and 10 patients received VNS implantation. The patients were monitored for more than 12 months after treatment, and seizure rates and complications were retrospectively evaluated. RESULTS: Seizure types among the 24 patients included atonic or tonic seizures with head-drops in 17 patients, generalized tonic seizures in two patients, atypical absence seizures in one patient, generalized tonic-clonic seizures in one patient, and myoclonic seizures in three patients. Of the 14 patients who underwent a corpus callosotomy, nine (64.3%) had a greater than 50% reduction in seizure frequency and five (35.7%) had a greater than 75% reduction. Of the 10 patients who underwent VNS implantation, seven (70.0%) had a greater than 50% reduction in seizure frequency and two (20.0%) had a greater than 75% reduction. There was no significant difference between the two procedures in terms of final efficacy. Complications of corpus callosotomy included aphasia in one patient, ataxia in another, and paresis in a third. Among patients receiving VNS, one patient experienced dyspnea while sleeping and one patient suffered from drooling. These complications were transient and tolerable, and were controlled by simple adjustments of VNS treatment parameters. CONCLUSION: The efficacy and safety of corpus callosotomy and VNS were comparable in children with LGS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent195~199-
dc.relation.isPartOfBRAIN & DEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHCorpus Callosum/surgery*-
dc.subject.MESHElectric Stimulation Therapy/methods*-
dc.subject.MESHEpilepsy/pathology-
dc.subject.MESHEpilepsy/therapy*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHMale-
dc.subject.MESHPsychosurgery/methods*-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVagus Nerve/physiopathology*-
dc.subject.MESHVagus Nerve/radiation effects-
dc.titleComparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorSu Jeong You-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorTae-Sung Ko-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorMi-Sun Yum-
dc.contributor.googleauthorYong Soon Hwang-
dc.contributor.googleauthorJung-Kyo Lee-
dc.contributor.googleauthorDong Suk Kim-
dc.contributor.googleauthorSang Keun Park-
dc.identifier.doi10.1016/j.braindev.2007.07.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01208-
dc.contributor.localIdA00402-
dc.relation.journalcodeJ00386-
dc.identifier.eissn1872-7131-
dc.identifier.pmid17825516-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0387760407001854-
dc.subject.keywordCorpus callosotomy-
dc.subject.keywordVagus nerve stimulation-
dc.subject.keywordLennox–Gastaut syndrome-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.rights.accessRightsnot free-
dc.citation.volume30-
dc.citation.number3-
dc.citation.startPage195-
dc.citation.endPage199-
dc.identifier.bibliographicCitationBRAIN & DEVELOPMENT, Vol.30(3) : 195-199, 2008-
dc.identifier.rimsid56351-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.