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Gender-related difference in arterial elastance during exercise in patients with hypertension

Authors
 Sungha Park  ;  Jong-Won Ha  ;  Chi Young Shim  ;  Eui-Young Choi  ;  Jin-Mi Kim  ;  Jeong-Ah Ahn  ;  Se-Wha Lee  ;  Se-Joong Rim  ;  Namsik Chung 
Citation
 HYPERTENSION, Vol.51(4) : 1163-1169, 2008 
Journal Title
HYPERTENSION
ISSN
 0194-911X 
Issue Date
2008
MeSH
Aged ; Arteries/physiology* ; Blood Pressure/physiology ; Echocardiography, Doppler ; Elasticity ; Exercise/physiology* ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology* ; Heart Rate/physiology ; Humans ; Hypertension/physiopathology* ; Male ; Middle Aged ; Sex Characteristics* ; Stroke Volume/physiology
Keywords
ender ; arterial elastance index ; heart failure ; exercise ; hypertension
Abstract
Exercise intolerance and heart failure with preserved ejection fraction are common in females. Recently, arterial stiffness has been suggested to be a significant contributor in the development of heart failure. How gender difference affects arterial stiffening and its response to exercise is not well known. We hypothesized that arterial elastance index during exercise would be more abnormal in females with hypertension than males. Arterial elastance index was estimated as arterial end systolic pressure/stroke volume controlled for body surface area and was measured at rest and during graded supine bicycle exercise (25 watts, 3-minute increments) in 298 patients with hypertension (149 males; 149 females; mean age, 59). The subjects were divided into 2 groups by gender. Exercise duration was significantly shorter in females compared to males (692+/-222 versus 483+/-128 seconds, P<0.001). Although arterial elastance index at baseline was significantly higher in males, the magnitude of increase was steeper in females with the magnitude of change at 75 W of exercise being significantly higher in females compared to males (0.69+/-0.83 versus 0.43+/-0.69, P=0.018). Arterial elastance index at each stage of exercise up to 75 W was independently associated with decreased exercise duration. In conclusion, despite lower arterial elastance index at rest, the increase during exercise was steeper in women with hypertension, suggesting a gender-related difference in dynamic arterial stiffness. The arterial elastance index during exercise was significantly associated with exercise duration in patients with hypertension
Files in This Item:
T200800164.pdf Download
DOI
10.1161/HYPERTENSIONAHA.107.106690
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Ahn, Jeong Ah(안정아)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106302
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