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Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Authors
 JE-HWAN LEE  ;  YOO HONG MIN  ;  CHUL WON CHUNG  ;  BYOUNG KOOK KIM  ;  HWI-JOONG YOON  ;  DEOG-YEON JO  ;  HO-JIN SHIN  ;  SOO-MEE BANG  ;  JONG-HO WON  ;  DAE YOUNG ZANG  ;  HYEOUNG JOON KIM  ;  HYUN-SOOK CHI  ;  KYOO-HYUNG LEE  ;  JUNE-WON CHEONG  ;  JIN SEOK KIM  ;  SUN HEE KIM  ;  SEONYANG PARK  ;  SU YON PARK  ;  JOO SEOP CHUNG  ;  JAE HOON LEE  ;  CHAN-JEOUNG PARK 
Citation
 LEUKEMIA & LYMPHOMA, Vol.49(4) : 700-709, 2008 
Journal Title
 LEUKEMIA & LYMPHOMA 
ISSN
 1042-8194 
Issue Date
2008
MeSH
Adolescent ; Adult ; Aged ; B-Lymphocytes ; Biomarkers/analysis ; Female ; Humans ; Immunophenotyping ; Korea ; Leukemia, Biphenotypic, Acute/mortality ; Leukemia, Biphenotypic, Acute/pathology* ; Male ; Middle Aged ; Myeloid Cells ; Prognosis ; Remission Induction ; Retrospective Studies ; Survival Analysis ; T-Lymphocytes
Keywords
Biphenotypic ; acute leukemia ; immunophenotype
Abstract
The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL
Full Text
http://informahealthcare.com/doi/abs/10.1080/10428190701843247
DOI
10.1080/10428190701843247
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Chung, Joo Won(정주원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106293
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