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Is albuminuria an indicator of myocardial dysfunction in diabetic patients without overt heart disease? A study with Doppler strain and strain rate imaging

Authors
 Chi Young Shim  ;  Sungha Park  ;  Eui-Young Choi  ;  Seok-Min Kang  ;  Bong-Soo Cha  ;  Jong-Won Ha  ;  Se-Joong Rim  ;  Hyun-Chul Lee  ;  Namsik Chung 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.57(4) : 448-452, 2008 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2008
MeSH
Aged ; Albuminuria/physiopathology* ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology* ; Diastole ; Echocardiography, Doppler* ; Female ; Humans ; Hypertrophy, Left Ventricular ; Male ; Middle Aged ; Ventricular Function, Left*
Keywords
Aged ; Albuminuria/physiopathology* ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology* ; Diastole ; Echocardiography, Doppler* ; Female ; Humans ; Hypertrophy, Left Ventricular ; Male ; Middle Aged ; Ventricular Function, Left*
Abstract
The aim of this study was to address whether albuminuria could predict myocardial dysfunction in diabetic patients without overt heart disease. We studied 67 patients with normal left ventricular (LV) ejection fraction and no evidence of LV hypertrophy or coronary artery disease (47 patients with type 2 diabetes mellitus and hypertension and 20 patients with hypertension only). Diabetes patients were divided into 3 groups based on albuminuria status: group II = no albuminuria (n = 20, <30 mg/d), group III = microalbuminuria (n = 13, 30-300 mg/d), and group IV = macroalbuminuria (n = 14, >300 mg/d). Twenty patients with hypertension only served as a control group (group I). Conventional 2-dimensional and Doppler echocardiography was done. Peak strain, peak systolic strain rate (SR), and peak diastolic SR of 6 LV segments in the apical views were measured and averaged in each patient. Conventional 2-dimensional parameters such as LV ejection fraction; left atrium volume index; LV mass; deceleration time; and mitral early peak, mitral late peak, myocardial early peak diastolic, and myocardial peak systolic velocities were not different among the 4 groups. However, peak strains were significantly lower in group III (P = .002) and group IV (P < .001) than in group I; and the absolute value of peak systolic SR was lower in group III (P = .033) and group IV (P < .001) than in group I. Furthermore, the value of peak diastolic SR was lower in group IV than in group I (P = .014). In diabetic patients with albuminuria, Doppler strain and SR imaging detected subclinical LV systolic and diastolic dysfunction; and albuminuria was associated with myocardial dysfunction in diabetic patients without overt heart disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049507003903
DOI
10.1016/j.metabol.2007.11.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Lee, Hyun Chul(이현철)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106292
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